BAIT
SLC6A4
5-HTT, AI323329, Htt, Sert, RP23-100P23.1
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
GO Process (22)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- brain morphogenesis [IMP]
- cellular response to cGMP [ISO]
- cellular response to organic substance [IDA]
- circadian rhythm [ISO]
- memory [ISO]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of organ growth [IMP]
- negative regulation of synaptic transmission, dopaminergic [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of gene expression [IMP]
- protein homooligomerization [ISO]
- protein oligomerization [ISO]
- response to toxic substance [ISO]
- serotonin transport [IMP, ISO]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [IGI]
- sodium ion transmembrane transport [ISO]
- sperm ejaculation [ISO]
- thalamus development [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
PPP1CA
Ppp1c, dism2
protein phosphatase 1, catalytic subunit, alpha isoform
GO Process (14)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- branching morphogenesis of an epithelial tube [IMP]
- cellular process [TAS]
- circadian regulation of gene expression [IDA]
- dephosphorylation [ISS]
- entrainment of circadian clock by photoperiod [IMP]
- female meiotic division [TAS]
- glycogen metabolic process [TAS]
- lung development [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- protein dephosphorylation [IDA, ISO, TAS]
- regulation of circadian rhythm [IDA, IMP, ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of glycogen catabolic process [ISO]
- regulation of translation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- PTW/PP1 phosphatase complex [ISO]
- cytoplasm [IDA, ISO]
- dendritic spine [ISO]
- extracellular vesicular exosome [ISO]
- glycogen granule [ISO]
- neuron projection [ISO]
- neuronal cell body [ISO]
- nucleoplasm [IDA, ISO]
- nucleus [IDA, ISO]
- perikaryon [ISO]
- plasma membrane [ISO]
- protein phosphatase type 1 complex [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states ... [more]
Front Mol Neurosci Jun. 26, 2020; 13();89 [Pubmed: 32581705]
Throughput
- High Throughput
Curated By
- BioGRID