BAIT

SLC6A4

5-HTT, AI323329, Htt, Sert, RP23-100P23.1
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Mus musculus
PREY

KCTD12

AU046135, AW538430, Pfet1, Pfetin
potassium channel tetramerisation domain containing 12
GO Process (1)
GO Function (2)
GO Component (4)
Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.

Quinlan MA, Robson MJ, Ye R, Rose KL, Schey KL, Blakely RD

Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states ... [more]

Front Mol Neurosci Jun. 26, 2020; 13();89 [Pubmed: 32581705]

Throughput

  • High Throughput

Curated By

  • BioGRID