BAIT
SLC6A4
5-HTT, AI323329, Htt, Sert, RP23-100P23.1
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
GO Process (22)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- brain morphogenesis [IMP]
- cellular response to cGMP [ISO]
- cellular response to organic substance [IDA]
- circadian rhythm [ISO]
- memory [ISO]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of organ growth [IMP]
- negative regulation of synaptic transmission, dopaminergic [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of gene expression [IMP]
- protein homooligomerization [ISO]
- protein oligomerization [ISO]
- response to toxic substance [ISO]
- serotonin transport [IMP, ISO]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [IGI]
- sodium ion transmembrane transport [ISO]
- sperm ejaculation [ISO]
- thalamus development [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
PHB
Bap32, RP23-17C2.2
prohibitin
GO Process (16)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- DNA biosynthetic process [IMP]
- cellular response to interleukin-6 [ISO]
- histone deacetylation [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of glucocorticoid receptor signaling pathway [ISO]
- negative regulation of transcription by competitive promoter binding [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- osteoblast differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- progesterone receptor signaling pathway [ISO]
- regulation of transcription, DNA-templated [ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of mitochondrial outer membrane [ISO]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- mitochondrial crista [ISO]
- mitochondrial inner membrane [IDA]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.
Altered serotonin (5-HT) signaling is associated with multiple brain disorders, including major depressive disorder (MDD), obsessive-compulsive disorder (OCD), and autism spectrum disorder (ASD). The presynaptic, high-affinity 5-HT transporter (SERT) tightly regulates 5-HT clearance after release from serotonergic neurons in the brain and enteric nervous systems, among other sites. Accumulating evidence suggests that SERT is dynamically regulated in distinct activity states ... [more]
Front Mol Neurosci Jun. 26, 2020; 13();89 [Pubmed: 32581705]
Throughput
- High Throughput
Curated By
- BioGRID