BAIT
LYN
p53Lyn, p56Lyn
LYN proto-oncogene, Src family tyrosine kinase
GO Process (77)
GO Function (16)
GO Component (17)
Gene Ontology Biological Process
- B cell homeostasis [ISO, ISS]
- B cell receptor signaling pathway [ISO]
- Fc receptor mediated inhibitory signaling pathway [ISO, ISS]
- Fc receptor mediated stimulatory signaling pathway [ISO, ISS]
- cell migration [IBA]
- cellular response to DNA damage stimulus [IBA, ISO]
- cellular response to extracellular stimulus [IEP]
- cellular response to heat [IEP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [ISO]
- chemotaxis [IBA]
- cytokine secretion [IMP]
- dendritic cell differentiation [IBA, ISO, ISS]
- erythrocyte differentiation [ISO, ISS]
- hemopoiesis [ISO]
- histamine secretion by mast cell [IMP]
- immune response-regulating cell surface receptor signaling pathway [ISO, ISS]
- innate immune response [IBA]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO, ISS]
- negative regulation of B cell proliferation [IBA, ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO, ISS]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of intracellular signal transduction [ISO, ISS]
- negative regulation of mast cell proliferation [IBA, ISO, ISS]
- negative regulation of myeloid leukocyte differentiation [ISO]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of toll-like receptor 2 signaling pathway [ISO, ISS]
- negative regulation of toll-like receptor 4 signaling pathway [ISO, ISS]
- neuron projection development [IBA, ISO]
- oligodendrocyte development [IEP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet degranulation [IBA, ISO, ISS]
- positive regulation of B cell receptor signaling pathway [ISO]
- positive regulation of Fc receptor mediated stimulatory signaling pathway [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of cellular component movement [ISO]
- positive regulation of dendritic cell apoptotic process [IBA, ISO, ISS]
- positive regulation of glial cell proliferation [IDA]
- positive regulation of mast cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of oligodendrocyte progenitor proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphorylation [IMP]
- positive regulation of stress-activated protein kinase signaling cascade [ISO]
- positive regulation of tyrosine phosphorylation of STAT protein [ISO, ISS]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of B cell apoptotic process [IBA, ISO]
- regulation of B cell receptor signaling pathway [IBA, ISO, ISS]
- regulation of ERK1 and ERK2 cascade [ISO, ISS]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cytokine production [ISO, ISS]
- regulation of cytokine secretion [ISO]
- regulation of erythrocyte differentiation [ISO, ISS]
- regulation of inflammatory response [ISO]
- regulation of mast cell activation [ISO, ISS]
- regulation of mast cell degranulation [IBA, ISO, ISS]
- regulation of monocyte chemotaxis [ISO]
- regulation of platelet aggregation [IBA, ISO, ISS]
- regulation of release of sequestered calcium ion into cytosol [IMP, ISO]
- response to amino acid [IEP]
- response to axon injury [IEP]
- response to carbohydrate [IEP]
- response to drug [IEP]
- response to hormone [ISO, ISS]
- response to insulin [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to sterol depletion [IEP]
- response to toxic substance [IEP]
- tolerance induction to self antigen [IBA, ISO, ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell [ISO]
- cell-cell adherens junction [IDA]
- cytoplasm [ISO, ISS]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- integrin alpha2-beta1 complex [IDA]
- mast cell granule [IMP]
- membrane [IDA]
- membrane raft [IDA, ISO]
- mitochondrial crista [IDA]
- mitochondrial intermembrane space [IDA]
- mitochondrial membrane [IDA]
- nucleus [ISO, ISS]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
PREY
PDGFRA
APDGFR, PDGFACE
platelet derived growth factor receptor, alpha polypeptide
GO Process (56)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- Leydig cell differentiation [ISO]
- adrenal gland development [ISO]
- anatomical structure morphogenesis [ISO]
- cardiac myofibril assembly [ISO, ISS]
- cell chemotaxis [ISO, ISS]
- cell migration [ISO]
- cellular response to amino acid stimulus [ISO]
- cellular response to platelet-derived growth factor stimulus [ISO]
- embryonic cranial skeleton morphogenesis [ISO, ISS]
- embryonic digestive tract morphogenesis [ISO, ISS]
- embryonic skeletal system morphogenesis [ISS]
- estrogen metabolic process [ISO]
- extracellular matrix organization [ISO]
- face morphogenesis [ISO]
- female gonad development [ISO]
- gliogenesis [IEP, NAS]
- hematopoietic progenitor cell differentiation [ISO]
- in utero embryonic development [ISO]
- inner ear development [IEP]
- lung development [ISO]
- luteinization [ISO, ISS]
- male genitalia development [ISO]
- metanephric glomerular capillary formation [ISO, ISS]
- negative regulation of platelet activation [ISO, ISS]
- odontogenesis of dentin-containing tooth [ISO]
- organ morphogenesis [ISO]
- palate development [ISO]
- peptidyl-tyrosine phosphorylation [ISO, ISS]
- phosphatidylinositol-mediated signaling [ISO, ISS]
- platelet aggregation [ISO, ISS]
- platelet-derived growth factor receptor signaling pathway [ISO, ISS]
- platelet-derived growth factor receptor-alpha signaling pathway [IDA, ISO]
- positive regulation of DNA replication [ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of cell migration [ISO, ISS]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO, ISS]
- positive regulation of fibroblast proliferation [ISO, ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO, ISS]
- positive regulation of phospholipase C activity [ISO]
- protein autophosphorylation [ISO, ISS]
- regulation of chemotaxis [ISO]
- regulation of mesenchymal stem cell differentiation [ISO, ISS]
- response to cytokine [IEP]
- response to estradiol [IEP]
- response to estrogen [IEP]
- response to hormone [IEP]
- response to hyperoxia [IEP]
- response to inorganic substance [IEP]
- response to organic substance [IEP]
- retina vasculature development in camera-type eye [ISO, ISS]
- signal transduction involved in regulation of gene expression [ISO]
- skeletal system morphogenesis [ISO]
- vascular endothelial growth factor signaling pathway [ISS]
- wound healing [IEP, ISO]
Gene Ontology Molecular Function- phosphatidylinositol 3-kinase binding [IPI]
- platelet-derived growth factor alpha-receptor activity [IDA, ISO, TAS]
- platelet-derived growth factor binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein complex binding [ISO]
- protein dimerization activity [NAS]
- protein homodimerization activity [ISO, ISS]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- vascular endothelial growth factor binding [ISO]
- vascular endothelial growth factor-activated receptor activity [ISO, ISS]
- phosphatidylinositol 3-kinase binding [IPI]
- platelet-derived growth factor alpha-receptor activity [IDA, ISO, TAS]
- platelet-derived growth factor binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein complex binding [ISO]
- protein dimerization activity [NAS]
- protein homodimerization activity [ISO, ISS]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- vascular endothelial growth factor binding [ISO]
- vascular endothelial growth factor-activated receptor activity [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes.
Human remyelination promoting IgM mAbs target oligodendrocytes (OLs) and function in animal models of multiple sclerosis (MS). However, their mechanism of action is unknown. This study seeks to identify the cellular mechanism of action of a recombinant human IgM on OL survival.Binding of rHIgM22 to the surface of rat OLs was studied by co-localization with various markers. RHIgM22-mediated effects on ... [more]
Glia Nov. 15, 2010; 58(15);1782-93 [Pubmed: 20645409]
Throughput
- Low Throughput
Curated By
- BioGRID