BAIT
LYN
p53Lyn, p56Lyn
LYN proto-oncogene, Src family tyrosine kinase
GO Process (77)
GO Function (16)
GO Component (17)
Gene Ontology Biological Process
- B cell homeostasis [ISO, ISS]
- B cell receptor signaling pathway [ISO]
- Fc receptor mediated inhibitory signaling pathway [ISO, ISS]
- Fc receptor mediated stimulatory signaling pathway [ISO, ISS]
- cell migration [IBA]
- cellular response to DNA damage stimulus [IBA, ISO]
- cellular response to extracellular stimulus [IEP]
- cellular response to heat [IEP]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to retinoic acid [ISO]
- chemotaxis [IBA]
- cytokine secretion [IMP]
- dendritic cell differentiation [IBA, ISO, ISS]
- erythrocyte differentiation [ISO, ISS]
- hemopoiesis [ISO]
- histamine secretion by mast cell [IMP]
- immune response-regulating cell surface receptor signaling pathway [ISO, ISS]
- innate immune response [IBA]
- intracellular signal transduction [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO, ISS]
- negative regulation of B cell proliferation [IBA, ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO, ISS]
- negative regulation of MAP kinase activity [ISO, ISS]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of intracellular signal transduction [ISO, ISS]
- negative regulation of mast cell proliferation [IBA, ISO, ISS]
- negative regulation of myeloid leukocyte differentiation [ISO]
- negative regulation of protein phosphorylation [ISO, ISS]
- negative regulation of toll-like receptor 2 signaling pathway [ISO, ISS]
- negative regulation of toll-like receptor 4 signaling pathway [ISO, ISS]
- neuron projection development [IBA, ISO]
- oligodendrocyte development [IEP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet degranulation [IBA, ISO, ISS]
- positive regulation of B cell receptor signaling pathway [ISO]
- positive regulation of Fc receptor mediated stimulatory signaling pathway [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of cellular component movement [ISO]
- positive regulation of dendritic cell apoptotic process [IBA, ISO, ISS]
- positive regulation of glial cell proliferation [IDA]
- positive regulation of mast cell proliferation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of oligodendrocyte progenitor proliferation [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phosphorylation [IMP]
- positive regulation of stress-activated protein kinase signaling cascade [ISO]
- positive regulation of tyrosine phosphorylation of STAT protein [ISO, ISS]
- protein autophosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of B cell apoptotic process [IBA, ISO]
- regulation of B cell receptor signaling pathway [IBA, ISO, ISS]
- regulation of ERK1 and ERK2 cascade [ISO, ISS]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cytokine production [ISO, ISS]
- regulation of cytokine secretion [ISO]
- regulation of erythrocyte differentiation [ISO, ISS]
- regulation of inflammatory response [ISO]
- regulation of mast cell activation [ISO, ISS]
- regulation of mast cell degranulation [IBA, ISO, ISS]
- regulation of monocyte chemotaxis [ISO]
- regulation of platelet aggregation [IBA, ISO, ISS]
- regulation of release of sequestered calcium ion into cytosol [IMP, ISO]
- response to amino acid [IEP]
- response to axon injury [IEP]
- response to carbohydrate [IEP]
- response to drug [IEP]
- response to hormone [ISO, ISS]
- response to insulin [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to sterol depletion [IEP]
- response to toxic substance [IEP]
- tolerance induction to self antigen [IBA, ISO, ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, ISO]
Gene Ontology Molecular Function- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
- SH3 domain binding [ISO]
- enzyme binding [IPI, ISO]
- gamma-tubulin binding [IDA]
- glycosphingolipid binding [IPI]
- integrin binding [IDA]
- ion channel binding [ISO]
- kinase activity [TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein complex binding [IDA, IPI, ISO]
- protein kinase activity [ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cell [ISO]
- cell-cell adherens junction [IDA]
- cytoplasm [ISO, ISS]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- integrin alpha2-beta1 complex [IDA]
- mast cell granule [IMP]
- membrane [IDA]
- membrane raft [IDA, ISO]
- mitochondrial crista [IDA]
- mitochondrial intermembrane space [IDA]
- mitochondrial membrane [IDA]
- nucleus [ISO, ISS]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
Rattus norvegicus
PREY
SRC
SRC proto-oncogene, non-receptor tyrosine kinase
GO Process (83)
GO Function (22)
GO Component (16)
Gene Ontology Biological Process
- activation of protein kinase B activity [IMP]
- adherens junction organization [IDA]
- bone resorption [IBA, ISO, ISS]
- branching involved in mammary gland duct morphogenesis [ISO]
- cell migration [ISO]
- cell proliferation [IDA]
- cellular response to fatty acid [IEP]
- cellular response to hypoxia [IEP]
- cellular response to insulin stimulus [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to platelet-derived growth factor stimulus [ISO]
- cellular response to progesterone stimulus [IMP]
- cellular response to transforming growth factor beta stimulus [ISO]
- central nervous system development [IBA]
- epidermal growth factor receptor signaling pathway [IEP]
- forebrain development [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO]
- intracellular estrogen receptor signaling pathway [IBA]
- intracellular signal transduction [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- negative regulation of mitochondrial depolarization [ISO]
- negative regulation of protein homooligomerization [ISO]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [IDA]
- oogenesis [ISO]
- osteoclast development [IBA, ISO]
- peptidyl-serine phosphorylation [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of DNA biosynthetic process [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of apoptotic process [IDA]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of cell adhesion [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]
- positive regulation of cytokine secretion [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of glucose metabolic process [IMP]
- positive regulation of insulin receptor signaling pathway [IDA]
- positive regulation of intracellular signal transduction [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of platelet-derived growth factor receptor signaling pathway [IEP]
- positive regulation of podosome assembly [ISO]
- positive regulation of protein autophosphorylation [IMP]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein transport [IMP]
- positive regulation of smooth muscle cell migration [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- progesterone receptor signaling pathway [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISO]
- regulation of caveolin-mediated endocytosis [ISO]
- regulation of cell projection assembly [ISO]
- regulation of cell proliferation [IBA]
- regulation of cell-cell adhesion [ISO]
- regulation of early endosome to late endosome transport [ISO]
- regulation of epithelial cell migration [ISO]
- regulation of intracellular estrogen receptor signaling pathway [ISO]
- regulation of podosome assembly [IBA]
- regulation of protein binding [ISO]
- response to acidic pH [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to fatty acid [IEP]
- response to hydrogen peroxide [IEP]
- response to interleukin-1 [ISO]
- response to mechanical stimulus [IEP]
- response to mineralocorticoid [IEP]
- response to nutrient levels [IEP]
- response to virus [IEP]
- single organismal cell-cell adhesion [IEP]
- stress fiber assembly [ISO]
- substrate adhesion-dependent cell spreading [ISO]
- transcytosis [IDA]
- transforming growth factor beta receptor signaling pathway [ISO]
- uterus development [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- cell adhesion molecule binding [IPI]
- enzyme binding [IPI, ISO]
- ephrin receptor binding [ISO]
- estrogen receptor binding [IPI]
- growth factor receptor binding [IBA, ISO]
- heme binding [ISO, ISS]
- insulin receptor binding [IPI]
- ion channel binding [ISO]
- kinase activity [ISO, TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI, ISO]
- scaffold protein binding [ISO]
- SH2 domain binding [ISO]
- cell adhesion molecule binding [IPI]
- enzyme binding [IPI, ISO]
- ephrin receptor binding [ISO]
- estrogen receptor binding [IPI]
- growth factor receptor binding [IBA, ISO]
- heme binding [ISO, ISS]
- insulin receptor binding [IPI]
- ion channel binding [ISO]
- kinase activity [ISO, TAS]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphoprotein binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein complex binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI, ISO]
- scaffold protein binding [ISO]
Gene Ontology Cellular Component
- actin filament [ISO]
- caveola [IDA, ISO]
- cytoplasm [ISO]
- cytosol [ISO, NAS, TAS]
- extracellular vesicular exosome [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- intracellular [ISO]
- late endosome [ISO]
- lysosome [ISO]
- mitochondrial inner membrane [ISO, ISS]
- mitochondrion [ISO]
- neuron projection [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- ruffle membrane [ISO]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes.
Human remyelination promoting IgM mAbs target oligodendrocytes (OLs) and function in animal models of multiple sclerosis (MS). However, their mechanism of action is unknown. This study seeks to identify the cellular mechanism of action of a recombinant human IgM on OL survival.Binding of rHIgM22 to the surface of rat OLs was studied by co-localization with various markers. RHIgM22-mediated effects on ... [more]
Glia Nov. 15, 2010; 58(15);1782-93 [Pubmed: 20645409]
Throughput
- Low Throughput
Curated By
- BioGRID