SMO
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- anterior/posterior pattern specification [IMP]
- astrocyte activation [IMP]
- atrial septum morphogenesis [IGI]
- axon extension involved in axon guidance [ISO]
- cell development [IMP]
- cell fate specification [IMP]
- central nervous system development [IGI]
- central nervous system neuron differentiation [IMP]
- cerebellar cortex morphogenesis [IMP]
- cerebral cortex development [IMP]
- detection of cell density by contact stimulus involved in contact inhibition [ISO]
- determination of left/right asymmetry in lateral mesoderm [IMP]
- determination of left/right symmetry [IMP]
- developmental growth [IMP]
- digestive tract development [IMP]
- dorsal/ventral neural tube patterning [IMP]
- dorsal/ventral pattern formation [IMP]
- embryonic organ development [IGI]
- epithelial-mesenchymal cell signaling [IMP]
- forebrain morphogenesis [IMP]
- hair follicle morphogenesis [IMP]
- heart looping [IMP]
- heart morphogenesis [IGI]
- homeostasis of number of cells within a tissue [IDA]
- in utero embryonic development [IMP]
- mammary gland epithelial cell differentiation [IMP]
- mesenchymal to epithelial transition involved in metanephric renal vesicle formation [IMP]
- midgut development [IMP]
- multicellular organism growth [IGI, IMP]
- myoblast migration [IGI]
- negative regulation of DNA binding [IGI, IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of epithelial cell differentiation [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of hair follicle development [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- neural crest cell migration [IGI]
- odontogenesis of dentin-containing tooth [IMP]
- ossification [IMP]
- osteoblast differentiation [IMP]
- pancreas morphogenesis [IMP]
- pattern specification process [IMP]
- positive regulation of branching involved in ureteric bud morphogenesis [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of hh target transcription factor activity [IMP]
- positive regulation of mesenchymal cell proliferation [IMP]
- positive regulation of neuroblast proliferation [IGI]
- positive regulation of protein import into nucleus [IGI]
- positive regulation of smoothened signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein localization to nucleus [IMP]
- protein stabilization [IDA]
- regulation of gene expression [IGI]
- regulation of heart morphogenesis [IMP]
- regulation of stem cell maintenance [IMP]
- skeletal muscle fiber development [IMP]
- smoothened signaling pathway [IGI, IMP, ISO]
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation [IMP]
- smoothened signaling pathway involved in ventral spinal cord patterning [IMP]
- somite development [IMP]
- thalamus development [IMP]
- type B pancreatic cell development [IMP]
- vasculogenesis [IMP]
- ventral midline determination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- axonal growth cone [ISO]
- caveola [ISO]
- ciliary membrane [IDA]
- cilium [IDA]
- cytoplasm [IDA, ISO]
- dendrite [ISO]
- dendritic growth cone [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IBA]
- intracellular membrane-bounded organelle [ISO]
- neuronal cell body [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- primary cilium [IDA]
ITSN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation.
The sonic hedgehog (Shh) pathway has essential roles in several processes during development of the vertebrate central nervous system (CNS). Here, we report that Shh regulates dendritic spine formation in hippocampal pyramidal neurons via a novel pathway that directly regulates the actin cytoskeleton. Shh signaling molecules Patched (Ptc) and Smoothened (Smo) are expressed in several types of postmitotic neurons, including ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SMO ITSN1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID