KCNB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AMIGO1
Gene Ontology Biological Process
- axonal fasciculation [ISO, ISS]
- axonogenesis [ISO]
- brain development [IBA]
- cell adhesion [ISO]
- cell-cell adhesion [IBA]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISO, ISS]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO, ISS]
- myelination [ISS]
- positive regulation of axonogenesis [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
AMIGO is an auxiliary subunit of the Kv2.1 potassium channel.
Kv2.1 is a potassium channel ?-subunit abundantly expressed throughout the brain. It is a main component of delayed rectifier current (I(K)) in several neuronal types and a regulator of excitability during high-frequency firing. Here we identify AMIGO (amphoterin-induced gene and ORF), a neuronal adhesion protein with leucine-rich repeat and immunoglobin domains, as an integral part of the Kv2.1 channel complex. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AMIGO1 KCNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KCNB1 AMIGO1 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.956 | BioGRID | 2677688 |
Curated By
- BioGRID