CHRNA3
Gene Ontology Biological Process
- activation of transmembrane receptor protein tyrosine kinase activity [ISS]
- behavioral response to nicotine [IMP]
- cation transmembrane transport [IDA, TAS]
- cation transport [IDA, TAS]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- locomotory behavior [ISS]
- nervous system development [IMP]
- regulation of acetylcholine secretion, neurotransmission [ISS]
- regulation of dendrite morphogenesis [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of membrane potential [ISS]
- regulation of smooth muscle contraction [ISS]
- signal transduction [IDA]
- synaptic transmission [TAS]
- synaptic transmission involved in micturition [IMP]
- synaptic transmission, cholinergic [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHRNB2
Gene Ontology Biological Process
- B cell activation [ISS]
- associative learning [ISS]
- behavioral response to nicotine [IMP]
- calcium ion transport [ISS]
- cation transmembrane transport [IDA, TAS]
- central nervous system projection neuron axonogenesis [ISS]
- cognition [IMP]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- lateral geniculate nucleus development [ISS]
- learning [IMP]
- locomotory behavior [ISS]
- membrane depolarization [ISS]
- memory [IMP]
- negative regulation of action potential [ISS]
- neurological system process [IMP]
- optic nerve morphogenesis [ISS]
- positive regulation of B cell proliferation [ISS]
- positive regulation of dopamine secretion [ISS]
- regulation of circadian sleep/wake cycle, REM sleep [ISS]
- regulation of dendrite morphogenesis [ISS]
- regulation of dopamine metabolic process [ISS]
- regulation of dopamine secretion [ISS]
- regulation of synapse assembly [ISS]
- regulation of synaptic transmission, dopaminergic [ISS]
- response to cocaine [ISS]
- response to ethanol [ISS]
- response to hypoxia [IDA]
- response to nicotine [IDA]
- sensory perception of pain [ISS]
- sensory perception of sound [ISS]
- signal transduction [IDA]
- smooth muscle contraction [ISS]
- social behavior [ISS]
- synaptic transmission [TAS]
- synaptic transmission involved in micturition [ISS]
- synaptic transmission, cholinergic [ISS]
- vestibulocochlear nerve development [ISS]
- visual learning [IMP]
- visual perception [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Presynaptic P2X1-3 and ?3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.
Previous studies documented a cross-talk between purinergic P2X (P2XR) and nicotinic acetylcholine receptors (nAChR) in heterologous expression systems and peripheral preparations. We now investigated if this occurred in native brain preparations and probed its physiological function. We found that P2XR and nAChR were enriched in hippocampal terminals, where both P2X1-3R and ?3, but not ?4, nAChR subunits were located in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHRNB2 CHRNA3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9938 | BioGRID | 3043910 | |
| CHRNB2 CHRNA3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID