P2RX2
Gene Ontology Biological Process
- cation transmembrane transport [IDA, NAS]
- cation transport [IDA, NAS]
- ion transmembrane transport [TAS]
- positive regulation of calcium ion transport into cytosol [NAS]
- positive regulation of calcium-mediated signaling [NAS]
- protein homooligomerization [IPI]
- purinergic nucleotide receptor signaling pathway [NAS]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CHRNA3
Gene Ontology Biological Process
- activation of transmembrane receptor protein tyrosine kinase activity [ISS]
- behavioral response to nicotine [IMP]
- cation transmembrane transport [IDA, TAS]
- cation transport [IDA, TAS]
- ion transmembrane transport [TAS]
- ion transport [NAS]
- locomotory behavior [ISS]
- nervous system development [IMP]
- regulation of acetylcholine secretion, neurotransmission [ISS]
- regulation of dendrite morphogenesis [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of membrane potential [ISS]
- regulation of smooth muscle contraction [ISS]
- signal transduction [IDA]
- synaptic transmission [TAS]
- synaptic transmission involved in micturition [IMP]
- synaptic transmission, cholinergic [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Presynaptic P2X1-3 and ?3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus.
Previous studies documented a cross-talk between purinergic P2X (P2XR) and nicotinic acetylcholine receptors (nAChR) in heterologous expression systems and peripheral preparations. We now investigated if this occurred in native brain preparations and probed its physiological function. We found that P2XR and nAChR were enriched in hippocampal terminals, where both P2X1-3R and ?3, but not ?4, nAChR subunits were located in ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CHRNA3 P2RX2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID