SSTR4
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- arachidonic acid metabolic process [IDA]
- cell migration [IDA, IMP]
- cellular response to glucocorticoid stimulus [IEP]
- forebrain development [IEP]
- negative regulation of cAMP metabolic process [IDA]
- negative regulation of cell proliferation [IBA]
- neuropeptide signaling pathway [IBA]
- positive regulation of MAPK cascade [IDA]
- somatostatin signaling pathway [IDA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
OPRD1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IBA]
- adenylate cyclase-activating dopamine receptor signaling pathway [ISO]
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway [ISO]
- adult locomotory behavior [ISO]
- cellular response to growth factor stimulus [IEP]
- cellular response to hypoxia [ISO]
- cellular response to toxic substance [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of protein oligomerization [ISO]
- neuropeptide signaling pathway [IBA, ISO]
- opioid receptor signaling pathway [IBA, ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- protein import into nucleus, translocation [ISO]
- regulation of calcium ion transport [IMP]
- regulation of mitochondrial membrane potential [ISO]
- regulation of sensory perception of pain [IDA]
- synaptic transmission [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
?-opioid receptor and somatostatin receptor-4 heterodimerization: possible implications in modulation of pain associated signaling.
Pain relief is the principal action of opioids. Somatostatin (SST), a growth hormone inhibitory peptide is also known to alleviate pain even in cases when opioids fail. Recent studies have shown that mice are prone to sustained pain and devoid of analgesic effect in the absence of somatostatin receptor 4 (SSTR4). In the present study, using brain slices, cultured neurons ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SSTR4 OPRD1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID