VAMP8
Gene Ontology Biological Process
- autophagic vacuole fusion [IMP]
- endocytosis [IBA]
- eosinophil degranulation [IMP]
- exocytosis [IBA]
- membrane organization [TAS]
- mucus secretion [IMP]
- negative regulation of secretion by cell [IDA]
- neutrophil degranulation [IMP]
- positive regulation of histamine secretion by mast cell [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- regulation of protein localization to plasma membrane [IDA]
- vesicle fusion [IBA]
- viral entry into host cell [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA]
- azurophil granule membrane [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- membrane [IDA]
- mucin granule [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- recycling endosome [IDA]
- secretory granule membrane [IDA, TAS]
- vesicle [IDA]
STX7
Gene Ontology Biological Process
- endosome to lysosome transport [IDA]
- intracellular protein transport [IBA]
- organelle assembly [ISO]
- organelle localization [ISO]
- positive regulation of T cell mediated cytotoxicity [ISO]
- positive regulation of receptor localization to synapse [ISO]
- regulation of protein localization to plasma membrane [ISO]
- synaptic vesicle exocytosis [TAS]
- vesicle docking [IBA]
- vesicle fusion [IDA]
- vesicle-mediated transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA]
- azurophil granule [ISO]
- early endosome [ISO]
- endocytic vesicle [ISO]
- endosome [IDA, ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [ISO]
- integral component of membrane [IBA]
- intracellular membrane-bounded organelle [ISO]
- late endosome [ISO]
- late endosome membrane [IDA]
- lysosomal membrane [IDA, ISO]
- lysosome [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- recycling endosome [ISO]
- terminal bouton [IDA]
- tertiary granule [ISO]
- vesicle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function.
Sets of SNARE proteins mediate membrane fusion by assembling into core complexes. Multiple SNAREs are thought to function in different intracellular trafficking steps but it is often unclear which of the SNAREs cooperate in individual fusion reactions. We report that syntaxin 7, syntaxin 8, vti1b and endobrevin/VAMP-8 form a complex that functions in the fusion of late endosomes. Antibodies specific ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID