BAIT

FAIM

FAIM1
Fas apoptotic inhibitory molecule
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

AP2M1

adaptor-related protein complex 2, mu 1 subunit
Mus musculus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.

Coccia E, Planells-Ferrer L, Badillos-Rodriguez R, Pascual M, Segura MF, Fernandez-Hernandez R, Lopez-Soriano J, Gari E, Soriano E, Barneda-Zahonero B, Moubarak RS, Perez-Garcia MJ, Comella JX

The long isoform of Fas apoptosis inhibitory molecule (FAIM-L) is a neuron-specific death receptor antagonist that modulates apoptotic cell death and mechanisms of neuronal plasticity. FAIM-L exerts its antiapoptotic action by binding to X-linked inhibitor of apoptosis protein (XIAP), an inhibitor of caspases, which are the main effectors of apoptosis. XIAP levels are regulated by the ubiquitin-proteasome pathway. FAIM-L interaction ... [more]

Cell Death Dis Dec. 03, 2019; 11(2);82 [Pubmed: 32015347]

Throughput

  • High Throughput

Curated By

  • BioGRID