BAIT
CIC
capicua transcriptional repressor
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
PDK3
CMTX6, GS1-358P8.4
pyruvate dehydrogenase kinase, isozyme 3
GO Process (11)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- cellular metabolic process [TAS]
- cellular response to fatty acid [IMP]
- cellular response to glucose stimulus [ISS]
- hypoxia-inducible factor-1alpha signaling pathway [IMP]
- peptidyl-serine phosphorylation [IDA]
- peroxisome proliferator activated receptor signaling pathway [IMP]
- pyruvate metabolic process [TAS]
- regulation of acetyl-CoA biosynthetic process from pyruvate [IMP, TAS]
- regulation of glucose metabolic process [IMP]
- regulation of reactive oxygen species metabolic process [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.
Oligodendrogliomas are brain tumors accounting for approximately 10% of all central nervous system cancers. CIC is a transcription factor that is mutated in most patients with oligodendrogliomas; these mutations are believed to be a key oncogenic event in such cancers. Analysis of the Drosophila melanogaster ortholog of CIC, Capicua, indicates that CIC loss phenocopies activation of the EGFR/RAS/MAPK pathway, and ... [more]
Cancer Res Dec. 01, 2017; 78(15);4114-4125 [Pubmed: 29844126]
Throughput
- High Throughput
Curated By
- BioGRID