BAIT
SQSTM1
A170, OSF-6, Osi, STAP, STONE14, p62, RP23-319B15.3
sequestosome 1
GO Process (7)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- autophagy [ISO]
- positive regulation of macroautophagy [IBA, ISO]
- positive regulation of protein phosphorylation [ISO]
- protein heterooligomerization [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- ubiquitin-dependent protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MMP9
AW743869, B/MMP9, Clg4b, MMP-9, pro-MMP-9, RP23-61O3.10-001
matrix metallopeptidase 9
GO Process (19)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- cellular response to cell-matrix adhesion [ISO]
- collagen catabolic process [IDA, ISO]
- embryo implantation [IDA]
- extracellular matrix organization [IGI, IMP]
- negative regulation of cation channel activity [ISO]
- negative regulation of fibroblast proliferation [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of keratinocyte migration [ISO]
- positive regulation of leukocyte migration [ISO]
- positive regulation of receptor binding [ISO]
- positive regulation of synaptic plasticity [ISO]
- protein oligomerization [ISO]
- proteolysis [IDA, ISO]
- response to drug [ISO]
- response to oxidative stress [ISO]
- skeletal system development [IGI, IMP]
- tissue remodeling [ISO]
- transformation of host cell by virus [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation.
Impaired macroautophagy/autophagy is involved in the pathogenesis of hepatic fibrosis. However, how aberrant autophagy promotes fibrosis is far from understood. Here, we aimed to define a previously unrevealed pro-fibrotic mechanism for the stress protein TRIB3 (tribbles pseudokinase 3)-mediated autophagy dysfunction. Human fibrotic liver tissues were obtained from patients with cirrhosis who underwent an open surgical repair process. The functional implications ... [more]
Autophagy Dec. 01, 2019; 16(5);782-796 [Pubmed: 31286822]
Throughput
- High Throughput
Curated By
- BioGRID