CD63
Gene Ontology Biological Process
- cell migration [ISO]
- cell-matrix adhesion [ISO]
- cellular protein localization [ISO]
- endosome to melanosome transport [ISO]
- epithelial cell differentiation [ISO]
- negative regulation of epithelial cell migration [ISO]
- pigment cell differentiation [IMP]
- pigment granule maturation [ISO]
- pigmentation [IMP]
- positive regulation of cell adhesion [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of integrin-mediated signaling pathway [ISO]
- positive regulation of receptor internalization [ISO]
- regulation of rubidium ion transport [ISO]
- regulation of vascular endothelial growth factor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [ISO]
- cytoplasm [ISO]
- endosome lumen [ISO]
- endosome membrane [ISO]
- extracellular vesicular exosome [ISO]
- intrinsic component of plasma membrane [ISO]
- late endosome [IDA]
- late endosome membrane [ISO]
- lysosomal membrane [ISO]
- lysosome [IDA, ISO]
- multivesicular body, internal vesicle [ISO]
- plasma membrane [ISO]
- protein complex [ISO]
LAMP1
Gene Ontology Biological Process
- Golgi to lysosome transport [ISO]
- autophagic cell death [ISO]
- establishment of protein localization to organelle [ISO]
- granzyme-mediated apoptotic signaling pathway [ISO]
- positive regulation of natural killer cell degranulation [ISO]
- positive regulation of natural killer cell mediated cytotoxicity [ISO]
- protein stabilization [IMP]
- regulation of organelle transport along microtubule [ISO]
- spermatogenesis [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- alveolar lamellar body [ISO]
- cell surface [IDA]
- cytolytic granule [IDA]
- cytoplasm [ISO]
- cytoplasmic vesicle [ISO]
- dendrite [ISO]
- endosome [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- late endosome [IDA, ISO]
- lysosome [IDA, ISO]
- melanosome [IDA]
- membrane [ISO]
- multivesicular body [IDA, ISO]
- neuronal cell body [ISO]
- phagolysosome membrane [IDA]
- plasma membrane [ISO]
- sarcolemma [IDA]
- synaptic vesicle [IDA]
- vacuole [ISO]
- vesicle [IDA]
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Disrupting the TRIB3-SQSTM1 interaction reduces liver fibrosis by restoring autophagy and suppressing exosome-mediated HSC activation.
Impaired macroautophagy/autophagy is involved in the pathogenesis of hepatic fibrosis. However, how aberrant autophagy promotes fibrosis is far from understood. Here, we aimed to define a previously unrevealed pro-fibrotic mechanism for the stress protein TRIB3 (tribbles pseudokinase 3)-mediated autophagy dysfunction. Human fibrotic liver tissues were obtained from patients with cirrhosis who underwent an open surgical repair process. The functional implications ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID