BAIT
UBR5
DD5, EDD, EDD1, HYD
ubiquitin protein ligase E3 component n-recognin 5
GO Process (11)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- cell proliferation [TAS]
- cellular response to DNA damage stimulus [IDA, IMP]
- negative regulation of double-strand break repair [IMP]
- negative regulation of histone H2A K63-linked ubiquitination [IMP]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of catenin import into nucleus [IMP]
- positive regulation of protein import into nucleus, translocation [IMP]
- progesterone receptor signaling pathway [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PDHB
PDHBD, PDHE1-B, PHE1B
pyruvate dehydrogenase (lipoamide) beta
GO Process (6)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.
N-end rule ubiquitination pathway is known to be disrupted in many diseases, including cancer. UBR5, an E3 ubiquitin ligase, is mutated and/or overexpressed in human lung cancer cells suggesting its pathological role in cancer.We determined expression of UBR5 protein in multiple lung cancer cell lines and human patient samples. Using immunoprecipitation followed by mass spectrometry we determined the UBR5 interacting ... [more]
BMC Cancer Aug. 31, 2020; 20(1);824 [Pubmed: 32867711]
Throughput
- High Throughput
Curated By
- BioGRID