BAIT
DTX1
hDx-1
deltex 1, E3 ubiquitin ligase
GO Process (7)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cell surface receptor signaling pathway [TAS]
- negative regulation of neuron differentiation [IGI]
- regulation of Notch signaling pathway [IGI]
- regulation of nucleic acid-templated transcription [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
TMEM126A
OPA7
transmembrane protein 126A
GO Process (1)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Cross-talk between ubiquitination and ADP-ribosylation regulates spatiotemporal recruitment of key players in many signaling pathways. The DELTEX family ubiquitin ligases (DTX1 to DTX4 and DTX3L) are characterized by a RING domain followed by a C-terminal domain (DTC) of hitherto unknown function. Here, we use two label-free mass spectrometry techniques to investigate the interactome and ubiquitinated substrates of human DTX2 and ... [more]
Sci Adv Aug. 01, 2020; 6(34); [Pubmed: 32937373]
Throughput
- High Throughput
Additional Notes
- proteins identified as binding partners from mass spectrometric analysis of co-immunoprecipited proteins if T-test difference was less than -2.61 and negative log of T-test p-value was greater than 1.33
Curated By
- BioGRID