BAIT
CCAR2
DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC
cell cycle and apoptosis regulator 2
GO Process (11)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- RNA splicing [IMP]
- mitochondrial fragmentation involved in apoptotic process [IDA]
- negative regulation of catalytic activity [IDA, IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [IMP]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of DNA damage checkpoint [IMP]
- positive regulation of apoptotic process [IMP]
- regulation of DNA-templated transcription, elongation [IMP]
- regulation of circadian rhythm [ISS]
- regulation of protein stability [IDA]
- response to UV [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
YWHAZ
14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
GO Process (13)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- Golgi reassembly [IMP]
- RNA metabolic process [TAS]
- apoptotic process [TAS]
- blood coagulation [TAS]
- establishment of Golgi localization [IMP]
- gene expression [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- mRNA metabolic process [TAS]
- membrane organization [TAS]
- negative regulation of apoptotic process [TAS]
- platelet activation [TAS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes.
Among all of the Super Elongation Complex (SEC) components, ELL1 (also known as ELL) is the only bona fide elongation factor that directly stimulates transcription elongation by RNA polymerase II. However, the mechanism(s) of functional regulation of ELL1 (referred to as ELL hereafter), through its stabilization, is completely unknown. Here, we report a function of human DBC1 in regulating ELL ... [more]
Proc Natl Acad Sci U S A Dec. 24, 2019; 117(12);6509-6520 [Pubmed: 32152128]
Throughput
- High Throughput
Curated By
- BioGRID