BAIT
APC2
APC, CG6193, D-APC2, Dm APC2, Dmel\CG6193, E-APC, E-APC dAPC2, dAPC2, dAPC2/E-APC, Dmel_CG6193
Adenomatous polyposis coli tumor suppressor homolog 2
GO Process (24)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- Wnt signaling pathway [TAS]
- axon guidance [IGI]
- brain development [IGI]
- cell adhesion [IMP, NAS]
- chitin-based embryonic cuticle biosynthetic process [IMP]
- chitin-based larval cuticle pattern formation [IGI]
- cortical actin cytoskeleton organization [IMP]
- cytokinesis [TAS]
- establishment of mitotic spindle localization [TAS]
- establishment or maintenance of microtubule cytoskeleton polarity [IMP]
- head involution [IGI]
- imaginal disc pattern formation [IGI]
- medulla oblongata development [IGI]
- microtubule-based process [ISS, TAS]
- negative regulation of Wnt signaling pathway [IGI]
- negative regulation of transcription, DNA-templated [TAS]
- neuroblast proliferation [IGI]
- oocyte localization involved in germarium-derived egg chamber formation [IGI, IMP]
- positive regulation of protein catabolic process [IGI]
- positive regulation of proteolysis [TAS]
- pseudocleavage involved in syncytial blastoderm formation [IMP]
- regulation of Wnt signaling pathway [IGI, IMP]
- single organismal cell-cell adhesion [IGI]
- syncytial nuclear migration [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
THUMPD1
THUMP domain containing 1
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.
Wnt signaling plays key roles in embryonic development and adult stem cell homeostasis and is altered in human cancer. Signaling is turned on and off by regulating stability of the effector ?-catenin (?-cat). The multiprotein destruction complex binds and phosphorylates ?-cat and transfers it to the SCF-TrCP E3-ubiquitin ligase for ubiquitination and destruction. Wnt signals act though Dishevelled to turn ... [more]
Mol Biol Cell Dec. 01, 2019; 31(10);992-1014 [Pubmed: 32129710]
Throughput
- High Throughput
Curated By
- BioGRID