BAIT
FLRT3
HH21, UNQ856/PRO1865
fibronectin leucine rich transmembrane protein 3
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UNC5B
UNC5H2, p53RDL1, RP11-58O1.1
unc-5 homolog B (C. elegans)
GO Process (7)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- apoptotic process [TAS]
- axon guidance [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of neuron apoptotic process [IMP]
- positive regulation of apoptotic process [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- regulation of apoptotic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons.
Netrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A-Unc5D). Mouse genetic analysis of selected members of the Unc5 family, however, revealed essential functions independent of Netrin-1, suggesting the presence of other ligands. Unc5B was recently shown to bind fibronectin and leucine-rich transmembrane protein-3 (FLRT3), although the relevance of this interaction for nervous system development remained ... [more]
EMBO J Jun. 14, 2011; 30(14);2920-33 [Pubmed: 21673655]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UNC5B FLRT3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID