EPHA7
Gene Ontology Biological Process
- brain development [IMP]
- branching morphogenesis of a nerve [IMP]
- ephrin receptor signaling pathway [IDA, ISO]
- negative chemotaxis [IDA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- phosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of neuron apoptotic process [IMP]
- regulation of ERK1 and ERK2 cascade [ISO]
- regulation of cell-cell adhesion [IDA]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of peptidyl-tyrosine phosphorylation [IDA, ISO]
- regulation of protein autophosphorylation [IDA]
- retinal ganglion cell axon guidance [IMP]
- signal transduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EFNA5
Gene Ontology Biological Process
- axon guidance [IDA, IMP]
- brain development [ISO]
- ephrin receptor signaling pathway [IDA, ISO]
- negative chemotaxis [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of Rac GTPase activity [IDA]
- regulation of Rho GTPase activity [ISO]
- regulation of actin cytoskeleton organization [IDA, ISO]
- regulation of cell-cell adhesion [IDA, ISO]
- regulation of focal adhesion assembly [ISO]
- regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- regulation of microtubule cytoskeleton organization [ISO]
- retinal ganglion cell axon guidance [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Silencing of EphA3 through a cis interaction with ephrinA5.
EphAs and ephrinAs are expressed in multiple areas of the developing brain in overlapping countergradients, notably in the retina and tectum. Here they are involved in targeting retinal axons to their correct topographic position in the tectum. We have used truncated versions of EphA3, single-amino acid point mutants of ephrinA5 and fluorescence resonance energy transfer technology to uncover a cis ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID