BAIT

VPS13

SOI1, VPT2, membrane morphogenesis protein VPS13, L000003510, L000002967, YLL040C
Protein involved in prospore membrane morphogenesis; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation during sporulatoin, and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
Saccharomyces cerevisiae (S288c)
PREY

CSG2

CLS2, mannosylinositol phosphorylceramide synthase regulatory subunit, L000002979, L000000427, YBR036C
Endoplasmic reticulum membrane protein; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Flavonoids as Potential Drugs for VPS13-Dependent Rare Neurodegenerative Diseases.

Soczewka P, Flis K, Tribouillard-Tanvier D, di Rago JP, Santos CN, Menezes R, Kaminska J, Zoladek T

Several rare neurodegenerative diseases, including chorea acanthocytosis, are caused by mutations in the VPS13A-D genes. Only symptomatic treatments for these diseases are available. Saccharomyces cerevisiae contains a unique VPS13 gene and the yeast vps13? mutant has been proven as a suitable model for drug tests. A library of drugs and an in-house library of natural compounds and their derivatives were ... [more]

Genes (Basel) Dec. 21, 2019; 11(7); [Pubmed: 32708255]

Throughput

  • Low Throughput

Ontology Terms

  • vegetative growth (APO:0000106)

Additional Notes

  • Figure 7
  • SDS

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
VPS13 CSG2
Negative Genetic
Negative Genetic

Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.

High-2.7497BioGRID
578476

Curated By

  • BioGRID