BAIT
FYN
AI448320, AW552119
Fyn proto-oncogene
GO Process (29)
GO Function (17)
GO Component (10)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IBA, ISO]
- activated T cell proliferation [IMP]
- cell surface receptor signaling pathway [IDA]
- cellular response to peptide hormone stimulus [IBA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IGI]
- dendrite morphogenesis [IMP]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- forebrain development [IGI, IMP]
- innate immune response [IBA]
- myelination [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of gene expression [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein catabolic process [IMP]
- neuron migration [IGI, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of neuron projection development [IGI]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein localization to nucleus [IDA]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IMP]
- regulation of apoptotic process [IBA]
- regulation of cell proliferation [IBA]
- regulation of cell shape [IDA]
- response to ethanol [IGI]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- G-protein coupled receptor binding [IPI]
- T cell receptor binding [ISO]
- ephrin receptor binding [ISO]
- glycoprotein binding [ISO]
- growth factor receptor binding [ISO]
- ion channel binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [ISO]
- tubulin binding [IDA]
- CD4 receptor binding [ISO]
- CD8 receptor binding [ISO]
- G-protein coupled receptor binding [IPI]
- T cell receptor binding [ISO]
- ephrin receptor binding [ISO]
- glycoprotein binding [ISO]
- growth factor receptor binding [ISO]
- ion channel binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [ISO]
- tubulin binding [IDA]
Gene Ontology Cellular Component
Mus musculus
PREY
PTK2
FAK, FRNK, Fadk, mKIAA4203, p125FAK
PTK2 protein tyrosine kinase 2
GO Process (50)
GO Function (12)
GO Component (14)
Gene Ontology Biological Process
- JNK cascade [ISO]
- MAPK cascade [ISO]
- angiogenesis [IMP]
- blood vessel development [IMP]
- cellular chloride ion homeostasis [ISO]
- cellular component movement [TAS]
- cellular response to transforming growth factor beta stimulus [IDA]
- central nervous system neuron axonogenesis [IMP]
- endothelial cell migration [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of nucleus localization [IDA]
- extracellular matrix organization [IMP]
- growth hormone receptor signaling pathway [ISO]
- innate immune response [IBA]
- integrin-mediated signaling pathway [ISO, TAS]
- microtubule cytoskeleton organization [IDA]
- negative regulation of anoikis [ISO]
- negative regulation of apoptotic process [IBA, ISO]
- negative regulation of axonogenesis [IMP]
- negative regulation of cell migration [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of organ growth [IGI]
- negative regulation of synapse assembly [IMP]
- neuron migration [IDA, IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [IMP]
- positive regulation of glial cell proliferation [ISO]
- positive regulation of phagocytosis [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of smooth muscle cell migration [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of synaptic transmission [ISO]
- positive regulation of vasodilation [ISO]
- protein autophosphorylation [IDA, IMP, ISO]
- regulation of cell adhesion [IBA]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of cell proliferation [ISO]
- regulation of cell shape [ISO]
- regulation of osteoblast differentiation [ISO]
- transforming growth factor beta receptor signaling pathway [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
- JUN kinase binding [ISO]
- SH2 domain binding [ISO]
- actin binding [ISO]
- identical protein binding [ISO]
- integrin binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [ISO]
- protein tyrosine kinase activity [IDA]
- receptor binding [IBA]
Gene Ontology Cellular Component
- apical plasma membrane [IDA, ISO]
- basolateral plasma membrane [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA, ISO]
- intercalated disc [ISO]
- lamellipodium [IDA]
- nuclear body [ISO]
- nucleolus [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
- stress fiber [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The EphA4 receptor regulates dendritic spine remodeling by affecting beta1-integrin signaling pathways.
Remodeling of dendritic spines is believed to modulate the function of excitatory synapses. We previously reported that the EphA4 receptor tyrosine kinase regulates spine morphology in hippocampal pyramidal neurons, but the signaling pathways involved were not characterized (Murai, K.K., L.N. Nguyen, F. Irie, Y. Yamaguchi, and E.B. Pasquale. 2003. Nat. Neurosci. 6:153-160). In this study, we show that EphA4 activation ... [more]
J Cell Biol Sep. 24, 2007; 178(7);1295-307 [Pubmed: 17875741]
Throughput
- Low Throughput
Curated By
- BioGRID