ITGA3
Gene Ontology Biological Process
- cell adhesion [ISO]
- dendritic spine maintenance [IGI, IMP]
- exploration behavior [IGI]
- fusion of sperm to egg plasma membrane [IMP]
- lung development [ISO]
- memory [IMP]
- negative regulation of Rho protein signal transduction [IGI]
- negative regulation of cell projection organization [ISO]
- nephron development [ISO]
- neuron migration [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of neuron projection development [ISO]
- regulation of BMP signaling pathway [ISO]
- regulation of Wnt signaling pathway [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- renal filtration [ISO]
- single-organism behavior [IMP]
- skin development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basolateral plasma membrane [IDA]
- cell periphery [ISO]
- cell surface [ISO]
- excitatory synapse [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- integrin alpha3-beta1 complex [ISO]
- invadopodium membrane [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- synapse [IDA]
- synaptic membrane [IDA]
SLC6A4
Gene Ontology Biological Process
- brain morphogenesis [IMP]
- cellular response to cGMP [ISO]
- cellular response to organic substance [IDA]
- circadian rhythm [ISO]
- memory [ISO]
- monoamine transport [ISO]
- negative regulation of cerebellar granule cell precursor proliferation [ISO]
- negative regulation of neuron differentiation [ISO]
- negative regulation of organ growth [IMP]
- negative regulation of synaptic transmission, dopaminergic [ISO]
- positive regulation of cell cycle [IMP]
- positive regulation of gene expression [IMP]
- protein homooligomerization [ISO]
- protein oligomerization [ISO]
- response to toxic substance [ISO]
- serotonin transport [IMP, ISO]
- serotonin uptake [IDA, IMP, ISO]
- social behavior [IGI]
- sodium ion transmembrane transport [ISO]
- sperm ejaculation [ISO]
- thalamus development [ISO]
- vasoconstriction [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
- Rab GTPase binding [ISO]
- actin filament binding [ISO]
- cocaine binding [ISO]
- monoamine transmembrane transporter activity [ISO]
- myosin binding [ISO]
- nitric-oxide synthase binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- serotonin transmembrane transporter activity [ISO]
- serotonin:sodium symporter activity [ISO]
- syntaxin-1 binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The Gain-of-Function Integrin ?3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.
Engagement of integrins by the extracellular matrix initiates signaling cascades that drive a variety of cellular functions, including neuronal migration and axonal pathfinding in the brain. Multiple lines of evidence link the ITGB3 gene encoding the integrin ?3 subunit with the serotonin (5-HT) system, likely via its modulation of the 5-HT transporter (SERT). The ITGB3 coding polymorphism Leu33Pro (rs5918, PlA2) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID