BAIT
PIK3C3
VPS34, hVps34
phosphatidylinositol 3-kinase, catalytic subunit type 3
GO Process (10)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- cytokinesis [IMP]
- early endosome to late endosome transport [IMP]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [IMP, TAS]
- phospholipid metabolic process [TAS]
- small molecule metabolic process [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
NHLRC1
EPM2A, EPM2B, MALIN, bA204B7.2
NHL repeat containing E3 ubiquitin protein ligase 1
GO Process (6)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Regulation of the autophagic PI3KC3 complex by laforin/malin E3-ubiquitin ligase, two proteins involved in Lafora disease.
Lafora progressive myoclonus epilepsy is a fatal rare neurodegenerative disorder characterized by the accumulation of insoluble abnormal glycogen deposits in the brain and peripheral tissues. Mutations in at least two genes are responsible for the disease: EPM2A, encoding the glucan phosphatase laforin, and EPM2B, encoding the RING-type E3-ubiquitin ligase malin. Both laforin and malin form a functional complex in which ... [more]
Biochim Biophys Acta Mol Cell Res Dec. 01, 2019; 1867(2);118613 [Pubmed: 31758957]
Throughput
- Low Throughput
Additional Notes
- Colocalization requires presence of EPM2A-EPM2B complex
Curated By
- BioGRID