BAIT
COPS5
CSN5, JAB1, MOV-34, SGN5
COP9 signalosome subunit 5
GO Process (9)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- cullin deneddylation [IDA]
- exosomal secretion [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein deneddylation [IMP]
- protein deubiquitination [IDA]
- regulation of JNK cascade [IDA]
- transcription from RNA polymerase II promoter [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CAMK2B
CAM2, CAMK2, CAMKB
calcium/calmodulin-dependent protein kinase II beta
GO Process (14)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- cytokine-mediated signaling pathway [TAS]
- interferon-gamma-mediated signaling pathway [TAS]
- positive regulation of dendritic spine morphogenesis [ISS]
- positive regulation of neuron projection development [ISS]
- positive regulation of synapse maturation [ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of calcium ion transport [TAS]
- regulation of dendritic spine development [TAS]
- regulation of long-term neuronal synaptic plasticity [TAS]
- regulation of skeletal muscle adaptation [TAS]
- regulation of synapse structural plasticity [TAS]
- signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5.
The COP9 signalosome (CSN) is an evolutionarily conserved multisubunit protein complex, which controls protein degradation through deneddylation and inactivation of cullin-RING ubiquitin E3 ligases (CRLs). Recently, the CSN complex has been linked to the NF-?B signaling pathway due to its association with the IKK complex. However, how the CSN complex is regulated in this signaling pathway remains unclear. Here, we ... [more]
J Proteome Res Dec. 06, 2019; 19(3);1119-1130 [Pubmed: 31950832]
Throughput
- High Throughput
Curated By
- BioGRID