NUDT16
Gene Ontology Biological Process
- IDP catabolic process [IDA]
- XDP catabolic process [IDA]
- adenosine to inosine editing [IMP]
- dITP catabolic process [ISS]
- mRNA catabolic process [IDA]
- negative regulation of rRNA processing [ISS]
- nucleobase-containing small molecule catabolic process [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- positive regulation of cell cycle process [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of double-strand break repair [IMP]
- proteolysis [IDA]
- small molecule metabolic process [TAS]
- snoRNA catabolic process [IDA]
Gene Ontology Molecular Function- GTP binding [IDA]
- ITP binding [IDA]
- XTP binding [IDA]
- cobalt ion binding [IDA]
- dIDP diphosphatase activity [EXP]
- dITP diphosphatase activity [ISS]
- inosine-diphosphatase activity [EXP]
- m7G(5')pppN diphosphatase activity [IDA]
- mRNA binding [IDA]
- magnesium ion binding [IDA]
- manganese ion binding [IDA]
- metalloexopeptidase activity [IDA]
- nucleotide phosphatase activity, acting on free nucleotides [IDA]
- protein homodimerization activity [IDA]
- snoRNA binding [IDA]
- GTP binding [IDA]
- ITP binding [IDA]
- XTP binding [IDA]
- cobalt ion binding [IDA]
- dIDP diphosphatase activity [EXP]
- dITP diphosphatase activity [ISS]
- inosine-diphosphatase activity [EXP]
- m7G(5')pppN diphosphatase activity [IDA]
- mRNA binding [IDA]
- magnesium ion binding [IDA]
- manganese ion binding [IDA]
- metalloexopeptidase activity [IDA]
- nucleotide phosphatase activity, acting on free nucleotides [IDA]
- protein homodimerization activity [IDA]
- snoRNA binding [IDA]
PARP1
Gene Ontology Biological Process
- DNA repair [TAS]
- cellular response to insulin stimulus [IDA]
- double-strand break repair [IMP]
- gene expression [TAS]
- macrophage differentiation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- protein ADP-ribosylation [IDA]
- protein poly-ADP-ribosylation [IDA]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation.
53BP1 controls two downstream subpathways, one mediated by PTIP and Artemis and the other by RIF1 and MAD2L2/Shieldin, to coordinate DNA repair pathway choices. However, the upstream regulator(s) of 53BP1 function in DNA repair remain unknown. We and others recently reported that TIRR associates with 53BP1 to stabilize it and prevents 53BP1 localization to DNA damage sites by blocking 53BP1 ... [more]
Throughput
- Low Throughput
Additional Notes
- DePARylation
Curated By
- BioGRID