BAIT

TARDBP

1190002A23Rik, C85084, TDP-43, Tdp43, RP23-331P21.5

TAR DNA binding protein

GO Process (5)

GO Function (7)

GO Component (2)

Gene Ontology Biological Process

3'-UTR-mediated mRNA stabilization [ISO]

RNA splicing [ISO]

negative regulation by host of viral transcription [ISO]

positive regulation of transcription from RNA polymerase II promoter [IDA]

transcription from RNA polymerase II promoter [IDA]

Gene Ontology Molecular Function

RNA binding [ISO]
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
double-stranded DNA binding [ISO]
identical protein binding [ISO]
mRNA 3'-UTR binding [ISO]
poly(A) RNA binding [ISO]
protein binding [IPI]

Gene Ontology Cellular Component

nucleoplasm [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

SFPQ

1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, AU021830, D4Ertd314e, Gm12940, OTTMUSG00000009329, PSF, REP1, RP23-153M14.2

splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

GO Process (7)

GO Function (6)

GO Component (5)

Gene Ontology Biological Process

alternative mRNA splicing, via spliceosome [ISO]

histone H3 deacetylation [IMP]

negative regulation of circadian rhythm [IMP]

negative regulation of transcription from RNA polymerase II promoter [ISO]

negative regulation of transcription, DNA-templated [IDA, IMP]

positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]

regulation of circadian rhythm [IMP]

Gene Ontology Molecular Function

core promoter binding [IDA]
histone deacetylase binding [ISO]
poly(A) RNA binding [ISO]
protein binding [IPI]
transcription regulatory region DNA binding [ISO]
transcription regulatory region sequence-specific DNA binding [IDA]

Gene Ontology Cellular Component

chromatin [ISO]

nuclear matrix [ISO]

nucleoplasm [ISO]

paraspeckles [IDA, ISO]

CRISPR Database VEGA MGI Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.

Wang G, Yang H, Yan S, Wang CE, Liu X, Zhao B, Ouyang Z, Yin P, Liu Z, Zhao Y, Liu T, Fan N, Guo L, Li S, Li XJ, Lai L

TAR DNA-binding protein 43 (TDP-43) is a nuclear protein, but it is redistributed in the neuronal cytoplasm in both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Because small transgenic animal models often lack cytoplasmic TDP-43, how the cytoplasmic accumulation of TDP-43 contributes to these diseases remains unclear. The current study is aimed at studying the mechanism of cytoplasmic ... [more]

Mol Neurodegener Sep. 03, 2015; 10();42 [Pubmed: 26334913]

Throughput

Low Throughput

Curated By

BioGRID