CACNB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CACNA1D
Gene Ontology Biological Process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [ISS]
- axon guidance [TAS]
- calcium ion import [IDA]
- calcium ion transmembrane transport [ISS]
- calcium ion transport [IDA]
- energy reserve metabolic process [TAS]
- membrane depolarization during action potential [IBA]
- membrane depolarization during cardiac muscle cell action potential [IC]
- membrane repolarization during SA node cell action potential [IMP]
- positive regulation of calcium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane repolarization [ISS]
- regulation of heart rate by cardiac conduction [IMP]
- regulation of insulin secretion [TAS]
- regulation of potassium ion transmembrane transport [ISS]
- regulation of potassium ion transmembrane transporter activity [ISS]
- sensory perception of sound [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- alpha-actinin binding [IPI]
- ankyrin binding [ISS]
- high voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity involved SA node cell action potential [IMP]
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential [IC]
- alpha-actinin binding [IPI]
- ankyrin binding [ISS]
- high voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity [IDA]
- voltage-gated calcium channel activity involved SA node cell action potential [IMP]
- voltage-gated calcium channel activity involved in cardiac muscle cell action potential [IC]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Biophysical properties, pharmacology, and modulation of human, neuronal L-type (alpha(1D), Ca(V)1.3) voltage-dependent calcium currents.
Voltage-dependent calcium channels (VDCCs) are multimeric complexes composed of a pore-forming alpha(1) subunit together with several accessory subunits, including alpha(2)delta, beta, and, in some cases, gamma subunits. A family of VDCCs known as the L-type channels are formed specifically from alpha(1S) (skeletal muscle), alpha(1C) (in heart and brain), alpha(1D) (mainly in brain, heart, and endocrine tissue), and alpha(1F) (retina). Neuroendocrine ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID