CXCR2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- acute inflammatory response to antigenic stimulus [IMP]
- cell surface receptor signaling pathway [ISO]
- cellular defense response [ISO]
- chemokine-mediated signaling pathway [ISO]
- chemotaxis [ISO]
- interleukin-8-mediated signaling pathway [ISO]
- metanephric tubule morphogenesis [IMP]
- midbrain development [IEP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of neutrophil apoptotic process [IMP]
- neutrophil activation [ISO]
- neutrophil chemotaxis [IMP, ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISO]
- positive regulation of angiogenesis [IMP]
- positive regulation of cardiac muscle cell apoptotic process [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of leukocyte chemotaxis [IMP]
- positive regulation of neutrophil chemotaxis [IMP]
- positive regulation of vascular permeability [IMP]
- receptor internalization [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIA3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- dendrite [IDA]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- ionotropic glutamate receptor complex [TAS]
- membrane [ISO]
- neuronal cell body [IDA]
- perikaryon [IDA]
- postsynaptic density [IDA]
- postsynaptic membrane [IBA, ISO]
- protein complex [IPI]
- synaptic cleft [IDA]
- terminal bouton [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Expression of AMPA-type glutamate receptors in HEK cells and cerebellar granule neurons impairs CXCL2-mediated chemotaxis.
We find that cerebellar granule neurons (CGN) obtained from newborn rats (p3) migrate in response to both CXC chemokine ligand-2 (CXCL2) and -12 (CXCL12), while CGN from p7 rats are unresponsive to CXCL2. The expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-type glutamate receptor 1 (GluR1) greatly impairs the chemotaxis induced by CXCL2 in CXCR2-expressing HEK cells. By immunoprecipitation, we show that CXCR2 is ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID