PIB2
Gene Ontology Cellular Component
GLN3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure.
Mechanical stresses, including high hydrostatic pressure, elicit diverse physiological effects on organisms. Gtr1, Gtr2, Ego1 (also known as Meh1) and Ego3 (also known as Slm4), central regulators of the TOR complex 1 (TORC1) nutrient signaling pathway, are required for the growth of Saccharomyces cerevisiae cells under high pressure. Here, we showed that a pressure of 25?MPa (?250?kg/cm2) stimulates TORC1 to ... [more]
Throughput
- Low Throughput
Ontology Terms
- chemical compound accumulation (APO:0000095)
Additional Notes
- Figure 6
- reduced glutamine accumulation
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GLN3 PIB2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.225 | BioGRID | 2107554 |
Curated By
- BioGRID