ARRB1
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [IDA]
- activation of MAPK activity [IDA]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [TAS]
- endocytosis [IDA]
- follicle-stimulating hormone signaling pathway [IDA]
- negative regulation of ERK1 and ERK2 cascade [IMP]
- negative regulation of GTPase activity [IDA]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of interleukin-8 production [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of protein ubiquitination [ISO]
- phototransduction [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- positive regulation of histone H4 acetylation [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein binding [ISO]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of protein ubiquitination [IMP]
- positive regulation of receptor internalization [ISO, ISS]
- positive regulation of smooth muscle cell apoptotic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor-mediated endocytosis [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [IDA, ISO, TAS]
- regulation of cAMP biosynthetic process [TAS]
- regulation of cAMP catabolic process [TAS]
- sensory perception of pain [TAS]
- sensory perception of touch [TAS]
- stress fiber assembly [ISO]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [IDA]
- G-protein coupled receptor binding [TAS]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [IMP]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [IDA]
- clathrin binding [TAS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- follicle-stimulating hormone receptor binding [IPI]
- histone acetyltransferase activity [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein phosphorylated amino acid binding [IMP]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- AP-2 adaptor complex binding [IDA]
- G-protein coupled receptor binding [TAS]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [IMP]
- alpha-1A adrenergic receptor binding [IPI]
- alpha-1B adrenergic receptor binding [IDA]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [IDA]
- clathrin binding [TAS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- estrogen receptor binding [IPI]
- follicle-stimulating hormone receptor binding [IPI]
- histone acetyltransferase activity [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphoprotein binding [IPI]
- protein binding [IPI]
- protein phosphorylated amino acid binding [IMP]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
RAD18
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
?arrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.
Cellular DNA is constantly under threat from internal and external insults, consequently multiple pathways have evolved to maintain chromosomal fidelity. Our previous studies revealed that chronic stress, mediated by continuous stimulation of the ?2-adrenergic-?arrestin-1 signaling axis suppresses activity of the tumor suppressor p53 and impairs genomic integrity. In this pathway, ?arrestin-1 (?arr1) acts as a molecular scaffold to promote the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARRB1 RAD18 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID