CNTNAP2
Gene Ontology Biological Process
- adult behavior [IMP]
- brain development [TAS]
- cellular protein localization [ISS]
- cerebral cortex development [IEP]
- clustering of voltage-gated potassium channels [ISS]
- learning [IMP]
- limbic system development [IEP]
- neuron projection development [ISS]
- neuron recognition [NAS]
- protein localization to juxtaparanode region of axon [ISS]
- social behavior [IMP]
- striatum development [IEP]
- superior temporal gyrus development [IEP]
- thalamus development [IEP]
- transmission of nerve impulse [NAS]
- vocalization behavior [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CANX
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation.
Although genetic variations in several genes encoding for synaptic adhesion proteins have been found to be associated with autism spectrum disorders, one of the most consistently replicated genes has been CNTNAP2, encoding for contactin-associated protein-like 2 (CASPR2), a multidomain transmembrane protein of the neurexin superfamily. Using immunofluorescence confocal microscopy and complementary biochemical techniques, we compared wild-type CASPR2 to 12 point ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID