BAIT
POU4F2
BRN3.2, BRN3B, Brn-3b
POU class 4 homeobox 2
GO Process (8)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- MAPK cascade [IDA]
- axon guidance [ISS]
- intracellular estrogen receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neuron differentiation [ISS]
- positive regulation of cell differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- retina development in camera-type eye [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
Homo sapiens
PREY
NGFR
CD271, Gp80-LNGFR, TNFRSF16, p75(NTR), p75NTR
nerve growth factor receptor
GO Process (14)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- apoptotic signaling pathway [TAS]
- circadian regulation of gene expression [ISS]
- glucose homeostasis [ISS]
- intracellular protein transport [ISS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of axonogenesis [TAS]
- negative regulation of cell cycle [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of axonogenesis [TAS]
- regulation of axonogenesis [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of glucose import in response to insulin stimulus [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Egr-1 and Hipk2 are required for the TrkA to p75(NTR) switch that occurs downstream of IGF1-R.
The aging program mediated by IGF1-R is responsible for a naturally occurring TrkA to p75(NTR) switch that leads to activation of the second messenger ceramide and increased production of the Alzheimer's disease amyloid beta-peptide. Biochemical and genetic approaches that target IGF1-R signaling, p75(NTR), or ceramide are able to block the above events. Here, we show that the transcription factors Egr-1 ... [more]
Neurobiol Aging Dec. 01, 2009; 30(12);2010-20 [Pubmed: 18378044]
Throughput
- Low Throughput
Additional Notes
- ChIP
Curated By
- BioGRID