BAIT
FNDC5
1500001L03Rik, AI836596, C87088, PeP, Pxp, RP23-284L6.4
fibronectin type III domain containing 5
GO Process (2)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
AKT1
Akt, PKB, PKB/Akt, PKBalpha, Rac
thymoma viral proto-oncogene 1
GO Process (82)
GO Function (15)
GO Component (12)
Gene Ontology Biological Process
- activation-induced cell death of T cells [ISO]
- aging [ISO]
- anagen [IMP]
- apoptotic mitochondrial changes [IDA]
- cell projection organization [ISO]
- cellular response to epidermal growth factor stimulus [IDA]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to hypoxia [ISO]
- cellular response to insulin stimulus [IDA, IMP, ISO]
- cellular response to mechanical stimulus [ISO]
- cellular response to organic cyclic compound [ISO]
- cellular response to peptide [IDA]
- cellular response to prostaglandin E stimulus [IDA]
- cytoskeleton organization [TAS]
- execution phase of apoptosis [IDA]
- germ cell development [IDA]
- glucose homeostasis [IMP]
- glucose metabolic process [IMP]
- glucose transport [IMP]
- glycogen biosynthetic process [ISO]
- glycogen cell differentiation involved in embryonic placenta development [IMP]
- glycogen metabolic process [IMP]
- inflammatory response [IDA]
- insulin receptor signaling pathway [IMP, ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [IMP]
- maternal placenta development [IMP]
- negative regulation of JNK cascade [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of autophagy [ISO]
- negative regulation of cell size [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of fatty acid beta-oxidation [ISO]
- negative regulation of plasma membrane long-chain fatty acid transport [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of proteolysis [ISO]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- osteoblast differentiation [IGI]
- peptidyl-serine phosphorylation [IDA, ISO]
- peripheral nervous system myelin maintenance [IMP]
- phosphorylation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle [ISO]
- positive regulation of endothelial cell proliferation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of fat cell differentiation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of lipid biosynthetic process [ISO]
- positive regulation of nitric oxide biosynthetic process [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of sodium ion transport [IDA, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of vasoconstriction [ISO]
- protein catabolic process [IDA]
- protein import into nucleus, translocation [ISO]
- protein kinase B signaling [IGI]
- protein phosphorylation [IDA, ISO]
- protein ubiquitination [IDA]
- regulation of cell migration [ISO]
- regulation of glycogen biosynthetic process [ISO]
- regulation of myelination [IMP]
- regulation of neuron projection development [IDA]
- regulation of protein localization [IDA, ISO]
- response to UV-A [ISO]
- response to fluid shear stress [ISO]
- response to food [IDA]
- response to hormone [IDA]
- signal transduction [ISO]
- striated muscle cell differentiation [IGI]
- translation [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- enzyme binding [ISO]
- identical protein binding [ISO]
- kinase activity [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol-3,4,5-trisphosphate binding [ISO]
- phosphatidylinositol-3,4-bisphosphate binding [ISO]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [IPI]
- protein phosphatase 2A binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- protein serine/threonine/tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Irisin Mediates Effects on Bone and Fat via ?V Integrin Receptors.
Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to have beneficial effects in adipose tissues, brain, and bone. However, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified. Here we show that irisin binds to proteins of the ... [more]
Cell Dec. 13, 2017; 175(7);1756-1768.e17 [Pubmed: 30550785]
Throughput
- High Throughput
Curated By
- BioGRID