BAIT

FNDC5

1500001L03Rik, AI836596, C87088, PeP, Pxp, RP23-284L6.4

fibronectin type III domain containing 5

GO Process (2)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

positive regulation of brown fat cell differentiation [IDA]

response to muscle activity [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

endoplasmic reticulum [IDA]

extracellular region [IDA]

plasma membrane [IDA]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

PREY

ACTB

Actx, E430023M04Rik, beta-actin

actin, beta

GO Process (4)

GO Function (8)

GO Component (16)

Gene Ontology Biological Process

ATP-dependent chromatin remodeling [ISO]

axonogenesis [ISO]

cellular response to electrical stimulus [ISO]

platelet aggregation [ISO]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
Tat protein binding [ISO]
kinesin binding [ISO]
nitric-oxide synthase binding [ISO]
nucleosomal DNA binding [ISO]
protein binding [IPI]
protein kinase binding [ISO]

Gene Ontology Cellular Component

MLL5-L complex [ISO]

NuA4 histone acetyltransferase complex [ISO]

blood microparticle [ISO]

cortical cytoskeleton [IDA]

cytoplasmic ribonucleoprotein granule [ISO]

extracellular space [ISO]

extracellular vesicular exosome [ISO]

focal adhesion [ISO]

myelin sheath [IDA]

nuclear chromatin [ISO]

postsynaptic density [ISO]

protein complex [ISO]

ribonucleoprotein complex [ISO]

CRISPR Database MGI Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Irisin Mediates Effects on Bone and Fat via ?V Integrin Receptors.

Kim H, Wrann CD, Jedrychowski M, Vidoni S, Kitase Y, Nagano K, Zhou C, Chou J, Parkman VA, Novick SJ, Strutzenberg TS, Pascal BD, Le PT, Brooks DJ, Roche AM, Gerber KK, Mattheis L, Chen W, Tu H, Bouxsein ML, Griffin PR, Baron R, Rosen CJ, Bonewald LF, Spiegelman BM

Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to have beneficial effects in adipose tissues, brain, and bone. However, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified. Here we show that irisin binds to proteins of the ... [more]

Cell Dec. 13, 2017; 175(7);1756-1768.e17 [Pubmed: 30550785]

Throughput

High Throughput

Curated By

BioGRID