BAIT
NTRK1
Trk
neurotrophic tyrosine kinase, receptor, type 1
GO Process (42)
GO Function (9)
GO Component (13)
Gene Ontology Biological Process
- B cell differentiation [ISO]
- Sertoli cell development [IMP]
- aging [IEP]
- axon guidance [IMP]
- axonogenesis involved in innervation [ISO, ISS]
- cellular response to growth factor stimulus [IDA]
- cellular response to nerve growth factor stimulus [IDA]
- cellular response to nicotine [IDA]
- detection of mechanical stimulus involved in sensory perception of pain [IMP]
- detection of temperature stimulus involved in sensory perception of pain [IMP]
- developmental programmed cell death [IDA]
- learning or memory [IMP]
- mechanoreceptor differentiation [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of neuron apoptotic process [IMP, ISO]
- negative regulation of neuron death [IDA]
- nerve growth factor signaling pathway [IDA, ISO]
- nervous system development [ISO]
- neurotrophin TRK receptor signaling pathway [ISO, ISS]
- olfactory nerve development [IEP]
- peptidyl-tyrosine phosphorylation [IDA, ISO, ISS]
- positive regulation of ERK1 and ERK2 cascade [ISO, ISS]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of Ras GTPase activity [ISO, ISS]
- positive regulation of Ras protein signal transduction [ISO, ISS]
- positive regulation of angiogenesis [ISO]
- positive regulation of neuron projection development [ISO, ISS]
- positive regulation of programmed cell death [IDA]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISO, ISS]
- response to activity [IDA]
- response to axon injury [IEP]
- response to drug [IDA]
- response to electrical stimulus [IDA]
- response to ethanol [IEP]
- response to hydrostatic pressure [IEP]
- response to nicotine [IDA]
- response to nutrient levels [IDA]
- response to radiation [IEP]
- sensory perception of pain [IMP]
- sympathetic nervous system development [ISO, ISS]
Gene Ontology Molecular Function- ephrin receptor binding [IPI]
- kinase binding [IPI]
- nerve growth factor binding [IDA, ISO, ISS]
- nerve growth factor receptor activity [ISO, ISS]
- neurotrophin p75 receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- protein tyrosine kinase activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [ISO, ISS]
- ephrin receptor binding [IPI]
- kinase binding [IPI]
- nerve growth factor binding [IDA, ISO, ISS]
- nerve growth factor receptor activity [ISO, ISS]
- neurotrophin p75 receptor binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [ISO, ISS]
- protein tyrosine kinase activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
NTRK2
RATTRKB1, TRKB1, Tkrb, trk-B, trkB
neurotrophic tyrosine kinase, receptor, type 2
GO Process (44)
GO Function (8)
GO Component (24)
Gene Ontology Biological Process
- aging [IEP]
- brain-derived neurotrophic factor receptor signaling pathway [IDA, IMP, ISO]
- calcium-mediated signaling using intracellular calcium source [ISO]
- cellular response to brain-derived neurotrophic factor stimulus [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to tumor necrosis factor [IEP]
- central nervous system neuron development [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- feeding behavior [ISO]
- glutamate secretion [ISO]
- inflammatory response [IEP]
- learning [ISO, ISS]
- long-term memory [IDA]
- long-term synaptic potentiation [ISO]
- mechanoreceptor differentiation [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of neuron apoptotic process [IMP]
- neuromuscular junction development [ISO]
- neuron differentiation [ISO, ISS]
- neuron migration [ISO, ISS]
- neurotrophin signaling pathway [IDA, IMP, ISO]
- oligodendrocyte differentiation [ISO]
- peptidyl-tyrosine phosphorylation [IMP, ISO]
- peripheral nervous system neuron development [ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of axonogenesis [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [ISO, ISS]
- positive regulation of glucocorticoid receptor signaling pathway [IGI]
- positive regulation of neuron projection development [ISO, ISS]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- protein autophosphorylation [IDA, IMP]
- regulation of MAPK cascade [IDA]
- regulation of Rac GTPase activity [ISO, ISS]
- regulation of dendrite development [IMP]
- regulation of metabolic process [ISO]
- regulation of neurotransmitter secretion [IDA]
- regulation of protein kinase B signaling [ISO]
- response to auditory stimulus [IEP]
- response to light stimulus [IEP]
- retinal rod cell development [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- brain-derived neurotrophic factor binding [IDA, IMP, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [IPI]
- neurotrophin binding [IDA, ISO, ISS]
- neurotrophin receptor activity [IDA, IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IMP]
- brain-derived neurotrophic factor binding [IDA, IMP, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [IPI]
- neurotrophin binding [IDA, ISO, ISS]
- neurotrophin receptor activity [IDA, IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IMP]
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- axon [IDA]
- axon terminus [IDA]
- cell [ISO]
- cell surface [IDA]
- cytoplasm [IDA]
- cytosol [ISO]
- dendrite [IDA]
- dendritic spine [IDA]
- endosome [ISO]
- excitatory synapse [IDA]
- growth cone [IDA]
- integral component of plasma membrane [IDA, ISO]
- intracellular [ISO]
- neuronal cell body [IDA]
- neuronal postsynaptic density [ISO]
- perikaryon [IDA]
- plasma membrane [IDA, ISO, TAS]
- postsynaptic density [IDA]
- postsynaptic membrane [ISO]
- presynaptic active zone [IDA]
- receptor complex [ISO]
- rough endoplasmic reticulum [IDA]
- terminal bouton [ISO]
Rattus norvegicus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.
Neurotrophin (NT) receptors are coupled to numerous signaling networks that play critical roles in neuronal survival and plasticity. Several non-peptide small molecule ligands have recently been reported that bind to and activate specific tropomyosin-receptor kinase (Trk) NT receptors, stimulate their downstream signaling, and cause biologic effects similar to, though not completely overlapping, those of the native NT ligands. Here, in ... [more]
Neuropharmacology Dec. 01, 2015; 110(Pt A);343-361 [Pubmed: 27334657]
Throughput
- Low Throughput
Additional Notes
- Chimeric receptor
Curated By
- BioGRID