IRAK3
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- cytokine-mediated signaling pathway [ISS]
- interleukin-1-mediated signaling pathway [IMP]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of cytokine-mediated signaling pathway [IC]
- negative regulation of innate immune response [ISS]
- negative regulation of interleukin-12 production [IMP, ISS]
- negative regulation of interleukin-6 production [IMP, ISS]
- negative regulation of macrophage cytokine production [ISS]
- negative regulation of protein catabolic process [IMP]
- negative regulation of protein complex disassembly [IMP]
- negative regulation of toll-like receptor signaling pathway [ISS]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of macrophage tolerance induction [ISS]
- protein phosphorylation [IDA]
- regulation of protein complex disassembly [ISS]
- response to exogenous dsRNA [ISS]
- response to interleukin-1 [IMP]
- response to lipopolysaccharide [ISS]
- response to peptidoglycan [ISS]
- response to virus [IC]
- toll-like receptor signaling pathway [IBA]
Gene Ontology Molecular Function
RNF152
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
RNF152 positively regulates TLR/IL-1R signaling by enhancing MyD88 oligomerization.
Toll-like receptors (TLRs) are important pattern recognition receptors (PRRs) that are critical for the defense against invading pathogens. IL-1? is an important pro-inflammatory cytokine that also plays pivotal roles in shaping the adaptive immune response. TLRs and interleukin-1 receptor (IL-1R) share similar cytosolic domains and signaling processes. In this study, we identify the E3 ubiquitin ligase RNF152 as a positive ... [more]
Throughput
- Low Throughput
Additional Notes
- Source of IRAK3 not clear
Curated By
- BioGRID