LINGO1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WNK3
Gene Ontology Biological Process
- negative regulation of apoptotic process [ISO]
- positive regulation of calcium ion transport [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of ion transmembrane transporter activity [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of rubidium ion transmembrane transporter activity [ISO]
- positive regulation of rubidium ion transport [ISO]
- positive regulation of sodium ion transmembrane transporter activity [ISO]
- positive regulation of sodium ion transport [ISO]
- protein autophosphorylation [ISO]
- regulation of ion homeostasis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.
LINGO-1 is a functional component of the Nogo receptor 1 · p75(NTR) · LINGO-1 and Nogo receptor 1 · TAJ (TNFRSF19/TROY)·LINGO-1 signaling complexes. It has recently been shown that LINGO-1 antagonists significantly improve neuronal survival after neural injury. However, the mechanism by which LINGO-1 signaling influences susceptibility to apoptosis remains unknown. In an effort to better understand how LINGO-1 regulates ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WNK3 LINGO1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID