BAIT
RBM39
CAPER, CAPERalpha, FSAP59, HCC1, RNPC2, RP11-353C18.2
RNA binding motif protein 39
GO Process (1)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TPM1
C15orf13, CMD1Y, CMH3, HTM-alpha, LVNC9, TMSA
tropomyosin 1 (alpha)
GO Process (17)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- cardiac muscle contraction [IMP]
- cellular component movement [TAS]
- cellular response to reactive oxygen species [IEP]
- cytoskeleton organization [TAS]
- muscle contraction [TAS]
- muscle filament sliding [ISS, TAS]
- negative regulation of cell migration [ISS]
- positive regulation of ATPase activity [ISS]
- positive regulation of cell adhesion [ISS]
- positive regulation of heart rate by epinephrine [ISS]
- positive regulation of stress fiber assembly [ISS]
- regulation of heart contraction [TAS]
- regulation of muscle contraction [TAS]
- ruffle organization [ISS]
- sarcomere organization [IMP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
- wound healing [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.
Indisulam is an aryl sulfonamide drug with selective anticancer activity. Its mechanism of action and the basis for its selectivity have so far been unknown. Here we show that indisulam promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation. Mutations in RBM39 that prevent its recruitment ... [more]
Science Dec. 28, 2016; 356(6336); [Pubmed: 28302793]
Throughput
- High Throughput
Additional Notes
- Proteins that associated with RBM39 (control with no indisulam treatment). Contaminants were removed.
Curated By
- BioGRID