BAIT
RPS6KA1
ribosomal protein S6 kinase, polypeptide A1
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of hepatic stellate cell activation [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
Gene Ontology Molecular Function
Rattus norvegicus
PREY
MAPK7
BMK-1, BMK1, ERK-5, ERK5, Erk5-T, PRKM7, RP23-155J3.2
mitogen-activated protein kinase 7
GO Process (18)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [ISO]
- cellular response to growth factor stimulus [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to laminar fluid shear stress [ISO]
- cellular response to transforming growth factor beta stimulus [ISO]
- negative regulation of NFAT protein import into nucleus [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of heterotypic cell-cell adhesion [ISO]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of response to cytokine stimulus [ISO]
- peptidyl-serine phosphorylation [IDA]
- positive regulation of protein metabolic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to stress [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of angiogenesis [IMP]
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.
The possible association between the membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1) and inflammation has been suggested, but the molecular mechanisms underlying this link, especially during atherogenesis, remain unclear. In endothelial cells (ECs) exposed to disturbed flow (d-flow), p90 ribosomal S6 kinase (p90RSK) bound to MAGI1, causing MAGI1-S741 phosphorylation and sentrin/SUMO-specific protease 2 T368 phosphorylation-mediated MAGI1-K931 deSUMOylation. MAGI1-S741 phosphorylation ... [more]
JCI Insight Dec. 04, 2018; 4(7); [Pubmed: 30944250]
Throughput
- Low Throughput
Curated By
- BioGRID