SHC1
Gene Ontology Biological Process
- MAPK cascade [ISO]
- actin cytoskeleton organization [ISO]
- actin cytoskeleton reorganization [IMP]
- activation of MAPK activity [IMP, ISO]
- aging [ISO]
- angiogenesis [IMP]
- epidermal growth factor receptor signaling pathway [IBA, IDA]
- heart development [IMP]
- insulin receptor signaling pathway [IBA, ISO]
- neuron differentiation [ISO]
- neuron projection development [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of vasoconstriction [ISO]
- regulation of cell proliferation [IMP]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
- ephrin receptor binding [IPI, ISO]
- epidermal growth factor receptor binding [ISO]
- insulin receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphoprotein binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IBA]
- protein phosphatase 2A binding [ISO]
- receptor tyrosine kinase binding [IPI, ISO]
Gene Ontology Cellular Component
NTRK3
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- activation of Ras GTPase activity [ISO]
- activation of protein kinase B activity [ISO]
- cellular response to retinoic acid [IEP]
- cochlea development [IEP]
- lens fiber cell differentiation [ISO]
- mechanoreceptor differentiation [ISO]
- modulation by virus of host transcription [IEP]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of cell death [IMP]
- negative regulation of protein phosphorylation [ISO]
- neuron fate specification [IMP]
- neuron migration [IMP]
- neurotrophin signaling pathway [IMP, ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of axon extension involved in regeneration [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of positive chemotaxis [ISO]
- protein autophosphorylation [IMP]
- response to axon injury [IEP]
- response to corticosterone [IEP]
- response to ethanol [IEP]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Early BDNF, NT-3, and NT-4 signaling events.
Much more is known about nerve growth factor (NGF) signaling than that initiated by brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or NT-4. We sought to study early BDNF, NT-3, and NT-4 signaling events. Using TrkB-expressing cells, we found that BDNF and NT-4 individually induced tyrosine phosphorylation of TrkB in a dose-dependent fashion. At maximally effective concentrations, BDNF or NT-4 induced ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID