PIK3R1
Gene Ontology Biological Process
- B cell differentiation [IMP]
- NFAT protein import into nucleus [IMP]
- cellular glucose homeostasis [IDA]
- cellular response to UV [IGI, IMP]
- cellular response to insulin stimulus [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IGI, IMP]
- glucose metabolic process [ISO]
- growth hormone receptor signaling pathway [ISO]
- insulin receptor signaling pathway [ISO]
- insulin-like growth factor receptor signaling pathway [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [IGI, IMP]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of blood pressure [ISO]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cell-matrix adhesion [IGI]
- negative regulation of heart rate [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of osteoclast differentiation [IGI]
- negative regulation of proteolysis [ISO]
- negative regulation of smooth muscle cell proliferation [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- phosphatidylinositol phosphorylation [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO, TAS]
- positive regulation of RNA splicing [ISO]
- positive regulation of cell migration [IGI, ISO]
- positive regulation of endoplasmic reticulum unfolded protein response [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of myoblast differentiation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription factor import into nucleus [IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of tumor necrosis factor production [IMP]
- protein phosphorylation [IDA]
- protein stabilization [ISO]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
- response to cAMP [ISO]
- response to endoplasmic reticulum stress [IDA, ISO]
- response to glucocorticoid [ISO]
- response to insulin [ISO]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [ISO, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [ISO]
- ATPase binding [ISO]
- ErbB-3 class receptor binding [ISO]
- calmodulin binding [ISO]
- estrogen receptor binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
- 1-phosphatidylinositol-3-kinase activity [ISO, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [ISO]
- ATPase binding [ISO]
- ErbB-3 class receptor binding [ISO]
- calmodulin binding [ISO]
- estrogen receptor binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [IPI, ISO]
- insulin-like growth factor receptor binding [ISO]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphoprotein binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase binding [ISO]
- protein phosphatase binding [ISO]
- receptor binding [ISO]
- receptor tyrosine kinase binding [ISO]
- transcription factor binding [IPI, ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
NTRK3
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- activation of Ras GTPase activity [ISO]
- activation of protein kinase B activity [ISO]
- cellular response to retinoic acid [IEP]
- cochlea development [IEP]
- lens fiber cell differentiation [ISO]
- mechanoreceptor differentiation [ISO]
- modulation by virus of host transcription [IEP]
- negative regulation of astrocyte differentiation [IMP]
- negative regulation of cell death [IMP]
- negative regulation of protein phosphorylation [ISO]
- neuron fate specification [IMP]
- neuron migration [IMP]
- neurotrophin signaling pathway [IMP, ISO]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of axon extension involved in regeneration [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of positive chemotaxis [ISO]
- protein autophosphorylation [IMP]
- response to axon injury [IEP]
- response to corticosterone [IEP]
- response to ethanol [IEP]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Early BDNF, NT-3, and NT-4 signaling events.
Much more is known about nerve growth factor (NGF) signaling than that initiated by brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or NT-4. We sought to study early BDNF, NT-3, and NT-4 signaling events. Using TrkB-expressing cells, we found that BDNF and NT-4 individually induced tyrosine phosphorylation of TrkB in a dose-dependent fashion. At maximally effective concentrations, BDNF or NT-4 induced ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID