BAIT
PLCG1
AI894140, Cded, Plc-1, Plc-gamma1, Plcg-1, RP23-393F23.4
phospholipase C, gamma 1
GO Process (14)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- T cell receptor signaling pathway [IDA]
- calcium ion transport [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- in utero embryonic development [IMP]
- inositol trisphosphate biosynthetic process [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein secretion [ISO]
- regulation of store-operated calcium channel activity [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
NTRK2
RATTRKB1, TRKB1, Tkrb, trk-B, trkB
neurotrophic tyrosine kinase, receptor, type 2
GO Process (44)
GO Function (8)
GO Component (24)
Gene Ontology Biological Process
- aging [IEP]
- brain-derived neurotrophic factor receptor signaling pathway [IDA, IMP, ISO]
- calcium-mediated signaling using intracellular calcium source [ISO]
- cellular response to brain-derived neurotrophic factor stimulus [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to tumor necrosis factor [IEP]
- central nervous system neuron development [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- feeding behavior [ISO]
- glutamate secretion [ISO]
- inflammatory response [IEP]
- learning [ISO, ISS]
- long-term memory [IDA]
- long-term synaptic potentiation [ISO]
- mechanoreceptor differentiation [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of neuron apoptotic process [IMP]
- neuromuscular junction development [ISO]
- neuron differentiation [ISO, ISS]
- neuron migration [ISO, ISS]
- neurotrophin signaling pathway [IDA, IMP, ISO]
- oligodendrocyte differentiation [ISO]
- peptidyl-tyrosine phosphorylation [IMP, ISO]
- peripheral nervous system neuron development [ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of axonogenesis [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [ISO, ISS]
- positive regulation of glucocorticoid receptor signaling pathway [IGI]
- positive regulation of neuron projection development [ISO, ISS]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- protein autophosphorylation [IDA, IMP]
- regulation of MAPK cascade [IDA]
- regulation of Rac GTPase activity [ISO, ISS]
- regulation of dendrite development [IMP]
- regulation of metabolic process [ISO]
- regulation of neurotransmitter secretion [IDA]
- regulation of protein kinase B signaling [ISO]
- response to auditory stimulus [IEP]
- response to light stimulus [IEP]
- retinal rod cell development [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- brain-derived neurotrophic factor binding [IDA, IMP, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [IPI]
- neurotrophin binding [IDA, ISO, ISS]
- neurotrophin receptor activity [IDA, IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IMP]
- brain-derived neurotrophic factor binding [IDA, IMP, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [IPI]
- neurotrophin binding [IDA, ISO, ISS]
- neurotrophin receptor activity [IDA, IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IMP]
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- axon [IDA]
- axon terminus [IDA]
- cell [ISO]
- cell surface [IDA]
- cytoplasm [IDA]
- cytosol [ISO]
- dendrite [IDA]
- dendritic spine [IDA]
- endosome [ISO]
- excitatory synapse [IDA]
- growth cone [IDA]
- integral component of plasma membrane [IDA, ISO]
- intracellular [ISO]
- neuronal cell body [IDA]
- neuronal postsynaptic density [ISO]
- perikaryon [IDA]
- plasma membrane [IDA, ISO, TAS]
- postsynaptic density [IDA]
- postsynaptic membrane [ISO]
- presynaptic active zone [IDA]
- receptor complex [ISO]
- rough endoplasmic reticulum [IDA]
- terminal bouton [ISO]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Early BDNF, NT-3, and NT-4 signaling events.
Much more is known about nerve growth factor (NGF) signaling than that initiated by brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or NT-4. We sought to study early BDNF, NT-3, and NT-4 signaling events. Using TrkB-expressing cells, we found that BDNF and NT-4 individually induced tyrosine phosphorylation of TrkB in a dose-dependent fashion. At maximally effective concentrations, BDNF or NT-4 induced ... [more]
Exp Neurol Sep. 01, 1999; 159(1);297-308 [Pubmed: 10486198]
Throughput
- Low Throughput
Curated By
- BioGRID