OPTN
Gene Ontology Biological Process
- Golgi organization [ISO]
- Golgi ribbon formation [IBA, ISO]
- Golgi to plasma membrane protein transport [ISO]
- cellular protein localization [IMP]
- cytokine secretion [ISO]
- defense response to Gram-negative bacterium [ISO]
- macroautophagy [ISO]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of receptor recycling [ISO]
- positive regulation of cell proliferation [ISO]
- protein homooligomerization [ISO]
- protein targeting to Golgi [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAP1LC3A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.
The precise degradation of dysfunctional mitochondria by mitophagy is essential for maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other proteins and thereby perform multiple biological functions within the cell. In this study, we investigated the role of HTT during mitophagy and analyzed the impact of the expansion of its polyglutamine (polyQ) tract. HTT is involved in different mitophagy ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| OPTN MAP1LC3A | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | 2905737 |
Curated By
- BioGRID