Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.

Franco-Iborra S, Plaza-Zabala A, Montpeyo M, Sebastian D, Vila M, Martinez-Vicente M

The precise degradation of dysfunctional mitochondria by mitophagy is essential for maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other proteins and thereby perform multiple biological functions within the cell. In this study, we investigated the role of HTT during mitophagy and analyzed the impact of the expansion of its polyglutamine (polyQ) tract. HTT is involved in different mitophagy ... [more]

Autophagy Feb. 24, 2020; ();1-18 [Pubmed: 32093570]

Throughput

Low Throughput

Additional Notes

Proximity Ligation Assay

Curated By

BioGRID

Interaction Summary

CALCOCO2

Gene Ontology Cellular Component

MAP1LC3A

Gene Ontology Biological Process

Gene Ontology Molecular Function

GABA receptor binding [IBA]microtubule binding [IBA, ISO]phosphatidylethanolamine binding [ISO]phospholipid binding [ISO]protein binding [IPI]