BAIT
FBP1
FBP, RP11-342C23.1
fructose-1,6-bisphosphatase 1
GO Process (14)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cellular response to drug [IDA]
- cellular response to magnesium ion [IDA]
- dephosphorylation [IDA, IMP]
- fructose 6-phosphate metabolic process [IDA]
- fructose metabolic process [TAS]
- gluconeogenesis [IMP, ISS, TAS]
- glucose metabolic process [TAS]
- negative regulation of Ras protein signal transduction [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of glycolytic process [IDA]
- protein homotetramerization [IDA]
- regulation of gluconeogenesis [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
KRT6A
CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3
keratin 6A
GO Process (2)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.
Breast cancer is a leading cause of death in women worldwide, but the underlying mechanisms of breast tumorigenesis remain unclear. Fructose-1, 6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, was recently shown to be a tumor suppressor in breast cancer. However, the mechanisms of FBP1 as a tumor suppressor in breast cancer remain to be explored. Here we showed that ... [more]
Mol Cancer Res Dec. 01, 2019; 18(5);787-796 [Pubmed: 32041737]
Throughput
- High Throughput
Curated By
- BioGRID