BAIT
FBP1
FBP, RP11-342C23.1
fructose-1,6-bisphosphatase 1
GO Process (14)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cellular response to drug [IDA]
- cellular response to magnesium ion [IDA]
- dephosphorylation [IDA, IMP]
- fructose 6-phosphate metabolic process [IDA]
- fructose metabolic process [TAS]
- gluconeogenesis [IMP, ISS, TAS]
- glucose metabolic process [TAS]
- negative regulation of Ras protein signal transduction [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of glycolytic process [IDA]
- protein homotetramerization [IDA]
- regulation of gluconeogenesis [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
RPS4X
CCG2, DXS306, RPS4, S4, SCAR, SCR10
ribosomal protein S4, X-linked
GO Process (16)
GO Function (2)
GO Component (10)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- SRP-dependent cotranslational protein targeting to membrane [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- multicellular organismal development [IMP]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- positive regulation of cell proliferation [IMP]
- positive regulation of translation [IMP]
- translation [IC, IMP, TAS]
- translational elongation [TAS]
- translational initiation [TAS]
- translational termination [TAS]
- viral life cycle [TAS]
- viral process [TAS]
- viral transcription [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.
Breast cancer is a leading cause of death in women worldwide, but the underlying mechanisms of breast tumorigenesis remain unclear. Fructose-1, 6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, was recently shown to be a tumor suppressor in breast cancer. However, the mechanisms of FBP1 as a tumor suppressor in breast cancer remain to be explored. Here we showed that ... [more]
Mol Cancer Res Dec. 01, 2019; 18(5);787-796 [Pubmed: 32041737]
Throughput
- High Throughput
Curated By
- BioGRID