ZWF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
YAP1
Gene Ontology Biological Process
- positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance [IMP]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- response to drug [IMP]
- response to heat [IMP]
- response to metal ion [IMP]
- response to singlet oxygen [IMP]
Gene Ontology Molecular Function
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
A reduced form of nicotinamide adenine dinucleotide phosphate-independent mechanism enhances oxidative and nitrosative stress tolerance in yeast cells lacking glucose-6-phosphate dehydrogenase activity.
The reduced form of nicotinamide adenine dinucleotide phosphate (NADPH), which is required for various redox systems involving antioxidative stress enzymes, is thus important for stress tolerance mechanisms. Here, we analyzed the stress response of the NADPH-depleted cells of Saccharomyces cerevisiae. A cell viability assay showed that the NADPH depletion induced by disruption of the ZWF1 gene encoding glucose-6-phosphate dehydrogenase, which ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: oxidative stress resistance (APO:0000083)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ZWF1 YAP1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1367 | BioGRID | 2172775 |
Curated By
- BioGRID