NR4A2
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- cellular response to extracellular stimulus [IDA, ISO]
- cellular response to oxidative stress [IMP]
- central nervous system neuron differentiation [IMP]
- central nervous system projection neuron axonogenesis [IMP]
- death [IMP]
- dopamine biosynthetic process [IMP]
- dopamine metabolic process [IMP]
- dopaminergic neuron differentiation [IDA]
- gene expression [IMP]
- general adaptation syndrome [IMP]
- habenula development [IMP]
- intracellular receptor signaling pathway [TAS]
- negative regulation of neuron apoptotic process [IMP]
- nervous system development [IMP]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- neuron migration [IMP]
- positive regulation of catalytic activity [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic development [IMP]
- regulation of dopamine metabolic process [IDA]
- regulation of gene expression [IMP]
- regulation of respiratory gaseous exchange [IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
- regulation of transcription, DNA-templated [IMP]
- response to amphetamine [IMP]
- response to hypoxia [IMP]
- response to inorganic substance [ISO]
- response to insecticide [ISO]
- transcription from RNA polymerase II promoter [IMP]
- transcription, DNA-templated [IDA, ISO]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA, ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA, ISO]
SGSM1
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease.
The canonical histopathological feature of Parkinson's disease (PD) is the loss of dopaminergic neurons in the ventral midbrain. Although the common sporadic/idiopathic form of PD most often presents clinically at around 60 years of age when the levels of striatal dopamine and numbers of ventral dopaminergic neurons are posited to have declined by 80 and 60%, respectively, the temporal pattern ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NR4A2 SGSM1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID